Vitamin E Microspheres Embedded Within a Biocompatible Film for Planar Delivery

被引：23

作者：

Borodina, Tatiana ^{[1
]}

Grigoriev, Dmitry ^{[1
]}

Markvicheva, Elena ^{[2
]}

Moehwald, Helmuth ^{[1
]}

Shchukin, Dmitry ^{[1
]}

机构：

[1] Max Planck Inst Colloids & Interfaces, Dept Interfaces, D-14424 Potsdam, Germany

[2] Russian Acad Sci, Shemyakin & Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia

来源：

ADVANCED ENGINEERING MATERIALS | 2011年 / 13卷 / 03期

关键词：

CALCIUM ALGINATE; ALPHA-TOCOPHEROL; DRUG-DELIVERY; GUM; RELEASE; NANOPARTICLES; ENCAPSULATION; LIPOSOMES; CARRIER; SYSTEM;

D O I：

10.1002/adem.201080047

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

We demonstrate a new one-batch approach to the fabrication of a biocompatible Ca-alginate film with embedded vitamin E-loaded microspheres that could be used for planar dermal drug delivery. Stable vitamin E microspheres, coated with gum acacia, are produced by ultrasonic treatment of a two-phase liquid system. The Fourier transform infrared spectroscopy indicates an interaction between biopolymer functional groups induced by ultrasonication. Confocal laser fluorescence microscopy, scanning electron microscopy (SEM) and atomic force microscopy (AFM) demonstrate a homogeneous microsphere distribution within the Ca-alginate polymer film. The kinetics of in vitro vitamin E release found for the polymer film with entrapped microspheres was much more sustained (100% in 96 h) compared to the polymer film with vitamin E embedded in the free state (100% in 5 h). The novelty of the proposed research involves the ultrasonic fabrication of loaded microspheres and formation of biodegradable coating directly doped with microspheres.

引用

页码：B123 / B130

页数：8

共 41 条

[1] Synthesis and characterization of PLGA nanoparticles [J].

Astete, Carlos E. ;

Sabliov, Cristina M. .

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 2006, 17 (03) :247-289

[2] Are sonochemically prepared α-amylase protein microspheres biologically active? [J].

Avivi , S. ;

Gedanken, A. .

ULTRASONICS SONOCHEMISTRY, 2007, 14 (01) :1-5

[3] Liposomes: Applications in medicine [J].

Banerjee, R .

JOURNAL OF BIOMATERIALS APPLICATIONS, 2001, 16 (01) :3-21

[4]

BARNETT SE, 1987, ANN ROY COLL SURG, V69, P153

[5] Controlled release of DNA from self-degrading microcapsules [J].

Borodina, Tatiana ;

Markvicheva, Elena ;

Kunizhev, Stanislav ;

Moehwald, Helmuth ;

Sukhorukov, Gleb B. ;

Kreft, Oliver .

MACROMOLECULAR RAPID COMMUNICATIONS, 2007, 28 (18-19) :1894-1899

[6] Ultrasound emulsification -: An overview [J].

Canselier, JR ;

Delmas, H ;

Wilhelm, AM ;

Abismaïl, B .

JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY, 2002, 23 (1-3) :333-349

[7] Ultrasonic synthesis of stable, functional lysozyme microbubbles [J].

Cavalieri, Francesca ;

Ashokkumar, Muthupandian ;

Grieser, Franz ;

Caruso, Frank .

LANGMUIR, 2008, 24 (18) :10078-10083

[8] Comparison of gum arabic, modified starch, and whey protein isolate as emulsifiers:: Influence of pH, CaCl2 and temperature [J].

Chanamai, R ;

McClements, DJ .

JOURNAL OF FOOD SCIENCE, 2002, 67 (01) :120-125

[9] From vesicle size distributions to bilayer elasticity via cryo-transmission and freeze-fracture electron microscopy [J].

Coldren, B ;

van Zanten, R ;

Mackel, MJ ;

Zasadzinski, JA ;

Jung, HT .

LANGMUIR, 2003, 19 (14) :5632-5639

[10]

DECRAECKER W, 2008, OCCUPATIONAL SKIN DI, P244

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