Nitric oxide moves myoglobin centre stage

被引：200

作者：

Brunori, M

机构：

[1] Univ Roma La Sapienza, Inst Pasteur, Fdn Cenci Bolognetti, I-00185 Rome, Italy

[2] Univ Roma La Sapienza, Dipartimento Sci Biochim, I-00185 Rome, Italy

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2001年 / 26卷 / 04期

关键词：

D O I：

10.1016/S0968-0004(01)01824-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It has been proposed that myoglobin (Mb), besides being an oxygen carrier, plays the role of a nitric oxide (NO) scavenger in heart and skeletal muscle. A paper reporting data obtained using perfused hearts isolated from either wild-type or Mb-knockout mice provides the first experimental evidence for this novel function of Mb. The biochemical basis underlying the effects of NO on cardiac function is outlined in this article, beginning with the idea that this gas is an inhibitor of cytochrome-c oxidase. Some of the consequences of this new role of Mb and a molecular mechanism to account for the high reactivity of oxymyoglobin with NO are also briefly discussed.

引用

页码：209 / 210

页数：2

共 21 条

[11] Disruption of myoglobin in mice induces multiple compensatory mechanisms [J].