Circulating MicroRNAs Biomarkers or Mediators of Cardiovascular Diseases?

被引：293

作者：

Fichtlscherer, Stephan ^{[2
]}

Zeiher, Andreas M. ^{[2
]}

Dimmeler, Stefanie ^{[1
]}

机构：

[1] Goethe Univ Frankfurt, Ctr Mol Med, Inst Cardiovasc Regenerat, D-60590 Frankfurt, Germany

[2] Goethe Univ Frankfurt, Div Cardiol, Dept Med 3, D-60590 Frankfurt, Germany

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2011年 / 31卷 / 11期

基金：

欧洲研究理事会;

关键词：

acute coronary syndromes; diabetes mellitus; biomarker; microRNAs; CORONARY-ARTERY-DISEASE; ACUTE MYOCARDIAL-INFARCTION; ENDOTHELIAL PROGENITOR CELLS; PERIPHERAL-BLOOD; VASCULAR INTEGRITY; MONONUCLEAR-CELLS; GENE-EXPRESSION; ANGIOGENESIS; PLASMA; SERUM;

D O I：

10.1161/ATVBAHA.111.226696

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

MicroRNAs (miRs) are small, noncoding RNAs that posttranscriptionally control gene expression by inhibiting protein translation or inducing target mRNA destabilization. Besides their intracellular function, recent studies demonstrate that miRs can be exported or released by cells and circulate with the blood in a remarkably stable form. The discovery of circulating miRs opens up intriguing possibilities to use the circulating miR patterns as biomarker for cardiovascular diseases. Cardiac injury as it occurs after acute myocardial infarction increases the circulating levels of several myocardial-derived miRs (eg, miR-1, miR-133, miR-499, miR-208), whereas patients with coronary artery disease or diabetes showed reduced levels of endothelial-enriched miRs, such as miR-126. This review article summarizes the current clinical and experimental studies addressing the role of circulating miRs as a diagnostic or prognostic biomarker in cardiovascular disease. In addition, the mechanisms by which miRs are released and their putative function as long-distance communicators are discussed. (Arterioscler Thromb Vasc Biol. 2011;31:2383-2390.)

引用

页码：2383 / 2390

页数：8

共 59 条

[41] Pervasive roles of microRNAs in cardiovascular biology [J].

Small, Eric M. ;

Olson, Eric N. .

NATURE, 2011, 469 (7330) :336-342

[42] Dicer dependent microRNAs regulate gene expression and functions in human endothelial cells [J].

Suarez, Yajaira ;

Fernandez-Hernando, Carlos ;

Pober, Jordan S. ;

Sessa, William C. .

CIRCULATION RESEARCH, 2007, 100 (08) :1164-1173

[43] NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses [J].

Taganov, Konstantin D. ;

Boldin, Mark P. ;

Chang, Kuang-Jung ;

Baltimore, David .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (33) :12481-12486

[44] Expression of miR-I 46a/b is associated with the Toll-like receptor 4 signal in coronary artery disease: effect of renin-angiotensin system blockade and statins on miRNA-I 46a/b and Toll-like receptor 4 levels [J].

Takahashi, Yuji ;

Satoh, Mamoru ;

Minami, Yoshitaka ;

Tabuchi, Tsuyoshi ;

Itoh, Tomonori ;

Nakamura, Motoyuki .

CLINICAL SCIENCE, 2010, 119 (9-10) :395-405

[45] Gene expression profiling in whole blood of patients with coronary artery disease [J].

Taurino, Chiara ;

Miller, William H. ;

McBride, Martin W. ;

McClure, John D. ;

Khanin, Raya ;

Moreno, Maria U. ;

Dymott, Jane A. ;

Delles, Christian ;

Dominiczak, Anna F. .

CLINICAL SCIENCE, 2010, 119 (7-8) :335-343

[46] MiR423-5p As a Circulating Biomarker for Heart Failure [J].

Tijsen, Anke J. ;

Creemers, Esther E. ;

Moerland, Perry D. ;

de Windt, Leon J. ;

van der Wal, Allard C. ;

Kok, Wouter E. ;

Pinto, Yigal M. .

CIRCULATION RESEARCH, 2010, 106 (06) :1035-U63

[47] Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells [J].

Valadi, Hadi ;

Ekstrom, Karin ;

Bossios, Apostolos ;

Sjostrand, Margareta ;

Lee, James J. ;

Lotvall, Jan O. .

NATURE CELL BIOLOGY, 2007, 9 (06) :654-U72

[48] Control of stress-dependent cardiac growth and gene expression by a microRNA [J].

van Rooij, Eva ;

Sutherland, Lillian B. ;

Qi, Xiaoxia ;

Richardson, James A. ;

Hill, Joseph ;

Olson, Eric N. .

SCIENCE, 2007, 316 (5824) :575-579

[49] MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins [J].

Vickers, Kasey C. ;

Palmisano, Brian T. ;

Shoucri, Bassem M. ;

Shamburek, Robert D. ;

Remaley, Alan T. .

NATURE CELL BIOLOGY, 2011, 13 (04) :423-U182

[50] Cardiac growth and angiogenesis coordinated by intertissue interactions [J].

Walsh, Kenneth ;

Shiojima, Ichiro .

JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (11) :3176-3179

← 1 2 3 4 5 6 →