Control of stress-dependent cardiac growth and gene expression by a microRNA

被引：1314

作者：

van Rooij, Eva

Sutherland, Lillian B.

Qi, Xiaoxia

Richardson, James A.

Hill, Joseph

Olson, Eric N. ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Dept Mol Biol, Dallas, TX 75390 USA

[2] Univ Texas, SW Med Ctr, Dept Pathol, Dallas, TX 75390 USA

[3] Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX 75390 USA

来源：

SCIENCE | 2007年 / 316卷 / 5824期

关键词：

D O I：

10.1126/science.1139089

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The heart responds to diverse forms of stress by hypertrophic growth accompanied by fibrosis and eventual diminution of contractility, which results from down-regulation of alpha-myosin heavy chain (alpha MHC) and up-regulation of beta MHC, the primary contractile proteins of the heart. We found that a cardiac-specific microRNA (miR-208) encoded by an intron of the alpha MHC gene is required for cardiomyocyte hypertrophy, fibrosis, and expression of beta MHC in response to stress and hypothyroidism. Thus, the alpha MHC gene, in addition to encoding a major cardiac contractile protein, regulates cardiac growth and gene expression in response to stress and hormonal signaling through miR-208.

引用

收藏

页码：575 / 579

页数：5

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