Modulation of DNA-Modified Gold-Nanoparticle Stability in Salt with Concatemeric Single-Stranded DNAs for Colorimetric Bioassay Development

被引：22

作者：

Ali, M. Monsur ^{[1
,2
]}

Kanda, Pushpinder ^{[1
,2
]}

Aguirre, Sergio D. ^{[1
,2
]}

Li, Yingfu ^{[1
,2
]}

机构：

[1] McMaster Univ, Dept Biochem & Biomed Sci, Hamilton, ON, Canada

[2] McMaster Univ, Dept Chem & Chem Biol, Hamilton, ON, Canada

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2011年 / 17卷 / 07期

基金：

加拿大自然科学与工程研究理事会;

关键词：

aptamers; biosensors; DNAzyme; gold; nanoparticles; ROLLING-CIRCLE AMPLIFICATION; NUCLEIC-ACIDS; AGGREGATION; APTAMER; NANOTECHNOLOGY; BIOSENSORS; DNAZYMES; NANOSTRUCTURES; REPLICATION; CHEMISTRY;

D O I：

10.1002/chem.201002677

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Golden island: Periodically assembled gold nanoparticles (AuNPs) on a long single-stranded DNA (ssDNA) with a repetitive sequence, produced by rolling circle amplification (RCA), form island-like, globular structures under salted conditions (see figure; green = short DNA probe, orange=AuNP, black=long ssDNA from RCA). The AuNPs in such islands retain their original red color whereas unassembled AuNPs form purple aggregates under the same conditions. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：2052 / 2056

页数：5

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