Fused pyrimidine based inhibitors of phosphodiesterase 7 (PDE7): synthesis and initial structure-activity relationships

被引：35

作者：

Kempson, J ^{[1
]}

Pitts, WJ

Barbosa, J

Guo, JQ

Omotoso, O

Watson, A

Stebbins, K

Starling, GC

Dodd, JH

Barrish, JC

Felix, R

Fischer, K

机构：

[1] Bristol Myers Squibb Co, Pharmaceut Res Inst, Princeton, NJ 08543 USA

[2] Cambridge Discovery Chem, Richmond, CA 94804 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 07期

关键词：

PDE7; pyrimidine;

D O I：

10.1016/j.bmcl.2005.02.025

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of fused pyrimidine based inhibitors of PDE7 have been derived from an earlier screening lead 1. The synthesis, structure-activity relationships (SAR) and selectivity against several other PDE family members are described. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1829 / 1833

页数：5

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