The structure and function of Francisella lipopolysaccharide

被引：103

作者：

Gunn, John S.

Ernst, Robert K.

机构：

[1] Ohio State Univ, Columbus, OH 43210 USA

[2] Ohio State Univ, Ctr Microbial Interface Biol, Columbus, OH 43210 USA

[3] Ohio State Univ, Dept Mol Virol, Columbus, OH 43210 USA

[4] Ohio State Univ, Dept Internal Med, Div Infect Dis, Columbus, OH 43210 USA

[5] Univ Washington, Dept Med, Div Allergy & Infect Dis, Seattle, WA 98195 USA

来源：

FRANCISELLA TULARENSIS: BIOLOGY, PATHOGENICITY, EPIDEMIOLOGY, AND BIODEFENSE | 2007年 / 1105卷

关键词：

LPS; lipopolysaccharide; gray variant; phase variation; LPS modification; LPS structure; lipid A; O-antigen;

D O I：

10.1196/annals.1409.006

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A key factor in the biology of Francisella spp. is lipopolysaccharide (LPS). Francisella LPS has many unique structural properties and poorly activates proinflammatory responses due to its lack of interaction with toll-like receptor 4 (TLR4). The LPS of this organism can be modified by various carbohydrates including glucose, mannose and galactosamine, which affect various aspects of virulence. Spontaneously occurring colony variants of F. tularensis have altered LPS. This altered LPS may account for the novel phenotypes of these variants that include effects on susceptibility to killing by normal human serum, intracellular survival and animal virulence. Mutants devoid of O-antigen (directed mutants in O-antigen biosynthetic genes) show reduced intracellular survival and mouse virulence. Thus, this surface component is important in F. tularensis pathogenesis, and the inability of the LPS to alarm the immune system coupled with its frequent modification/alteration likely aid the success of this pathogen during human infection.

引用

收藏

页码：202 / 218

页数：17

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