The novel cyclopropapyrroloindole (CPI) bisalkylators bearing 3,3′-(1,4-phenylene)diacryloyl group as a linker

被引：13

作者：

Fukuda, Y ^{[1
]}

Seto, S

Furuta, H

Ebisu, H

Oomori, Y

机构：

[1] Kyorin Pharmaceut Co Ltd, Cent Res Labs, Nogi, Tochigi 3290114, Japan

[2] Sagami Chem Res Ctr, Kanagawa 2290012, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 15期

关键词：

D O I：

10.1016/S0960-894X(98)00346-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The novel cyclopropapyrroloindole(CPI) bisalkylators were synthesized and their antitumor activity was evaluated. Among these derivatives, AT-760 (5a) in which the two 3-methoxycarbonyl-2-trifluoromethylCPI (MCTFCPI) moieties are connected with a 3,3'-(1,4-phenylene)diacryloyl group, was found to exhibit more prominent cytotoxicity and antitumor activity than U-77,779 (bizelesin) (1). (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2003 / 2004

页数：2

共 6 条

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Fukuda, Y ;

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Ebisu, H ;

Oomori, Y ;

Terashima, S .

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