3-nitropropionic acid (3-NPA), a potent antimycobacterial agent from endophytic fungi: Is 3-NPA in some plants produced by endophytes?

被引：67

作者：

Chomeheon, P

Wiyakrutta, S

Sriubolmas, N

Ngamrojanavanich, N

Isarangkul, D

Kittakoop, P

机构：

[1] Natl Ctr Genet Engn & Biotechnol BIOTEC, Natl Sci & Technol Dev Agcy, Pathum Thani 12120, Thailand

[2] Chulalongkorn Univ, Fac Sci, Program Biotechnol, Bangkok 10330, Thailand

[3] Chulalongkorn Univ, Fac Sci, Dept Chem, Bangkok 10330, Thailand

[4] Mahidol Univ, Fac Sci, Dept Microbiol, Bangkok 10700, Thailand

[5] Chulalongkorn Univ, Fac Pharmaceut Sci, Dept Microbiol, Bangkok 10330, Thailand

[6] Mahidol Univ, Ctr Biotechnol, Inst Sci & Technol Res & Dev, Bangkok 10700, Thailand

来源：

JOURNAL OF NATURAL PRODUCTS | 2005年 / 68卷 / 07期

关键词：

D O I：

10.1021/np050036a

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

3-Nitropropionic acid (3-NPA, 1) was found in extracts of several strains of endophytic fungi. 3-NPA (1) exhibited potent antimycobacterial activity with the minimum inhibition concentration of 3.3 mu M, but was inactive against NCI-H187, BC, KB, and Vero cell lines. Endophytes were found to produce high levels of 3-NPA (1), and therefore 3-NPA (1) accumulated in certain plants may be produced by the associated endophytes. 3-NPA (1) may be used as a chemotaxonomic marker for endophytic fungi. The structure of 3-hydroxypropionic acid, a nematicidal agent, should be revised to 3-NPA (1).

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页码：1103 / 1105

页数：3

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