A new asymmetric synthesis of the anti-tumor alkaloid (R)-(+)-Crispine A

被引：74

作者：

Allin, Steven M. ^{[1
]}

Gaskell, Sean N.

Towler, Joannah M. R.

Page, Philip C. Bulman

Saha, Basu

McKenzie, Michael J.

Martin, William P.

机构：

[1] Loughborough Univ Technol, Dept Chem, Loughborough LE11 3TU, Leics, England

[2] Loughborough Univ Technol, Dept Chem Engn, Loughborough LE11 3TU, Leics, England

[3] Charnwood Mol Ltd, Loughborough LE11 5GA, Leics, England

[4] GSK Pharmaceut, Stevenage SG1 2NY, Herts, England

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 72卷 / 23期

关键词：

D O I：

10.1021/jo071235x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] We report a novel, facile, and asymmetric approach for the synthesis of the anti-tumor alkaloid (+)-crispine A via a highly diastereoselective N-acyliminium cyclization reaction as a key synthetic step.

引用

页码：8972 / 8975

页数：4

共 24 条

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