The asymmetric synthesis of (2S,3R)-capreomycidine

被引：30

作者：

DeMong, DE ^{[1
]}

Williams, RM ^{[1
]}

机构：

[1] Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 21期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0040-4039(01)00487-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An improved asymmetric synthesis of the guanidine-containing amino acid (2S,3R)-capreomycidine has been achieved in seven steps and 28% overall yield. The key synthetic step involved a Mannich-type reaction between a chiral glycine aluminum enolate and the benzyl-imine of 3-tert-butyldimethylsiloxy-propionaldehyde. (C) 2001 Elsevier Science Ltd. AH rights reserved.

引用

页码：3529 / 3532

页数：4

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