Genetics of Type 1 Diabetes: What's Next?

被引:207
作者
Pociot, Flemming [1 ,2 ]
Akolkar, Beena [3 ]
Concannon, Patrick [4 ,5 ]
Erlich, Henry A. [6 ]
Julier, Cecile [7 ]
Morahan, Grant [8 ]
Nierras, Concepcion R. [9 ]
Todd, John A. [10 ]
Rich, Stephen S. [4 ,11 ]
Nerup, Jorn [1 ]
机构
[1] Hagedorn Res Inst, Dept Genome Biol, Gentofte, Denmark
[2] Lund Univ, CRC, Malmo, Sweden
[3] NIDDKD, Div Diabet Endocrinol & Metab Dis, NIH, Bethesda, MD 20892 USA
[4] Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA USA
[5] Univ Virginia, Dept Biochem & Mol Genet, Charlottesville, VA USA
[6] Roche Mol Syst, Pleasanton, CA USA
[7] INSERM, Ctr Natl Genotypage, U730, Evry, France
[8] Univ Western Australia, Ctr Diabet Res, Western Australian Inst Med Res, Perth, WA 6009, Australia
[9] Juvenile Diabet Res Fdn Int, New York, NY USA
[10] Univ Cambridge, Addenbrookes Hosp, Juvenile Diabet Res Fdn Wellcome Trust Diabet & I, Cambridge Inst Med Res,Dept Med Genet, Cambridge CB2 2QQ, England
[11] Univ Virginia, Dept Publ Hlth Sci, Charlottesville, VA USA
基金
英国惠康基金;
关键词
GENOME-WIDE ASSOCIATION; MAJOR HISTOCOMPATIBILITY COMPLEX; PANCREATIC BETA-CELL; REGULATORY T-CELLS; EXTENDED HUMAN MHC; SUSCEPTIBILITY LOCUS; MULTIPLEX FAMILIES; TYROSINE-PHOSPHATASE; AUTOIMMUNE-DISEASE; RISING INCIDENCE;
D O I
10.2337/db10-0076
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页码:1561 / 1571
页数:11
相关论文
共 82 条
[1]   Guilt beyond a reasonable doubt [J].
Altshuler, David ;
Daly, Mark .
NATURE GENETICS, 2007, 39 (07) :813-815
[2]   Extreme genetic risk for type 1A diabetes [J].
Aly, Theresa A. ;
Ide, Akane ;
Jahromi, Mohamed M. ;
Barker, Jennifer M. ;
Fernando, Maria S. ;
Babu, Sunanda R. ;
Yu, Liping ;
Miao, Dongmei ;
Erlich, Henry A. ;
Fain, Pamela R. ;
Barriga, Katherine J. ;
Norris, Jill M. ;
Rewers, Marian J. ;
Eisenbarth, George S. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (38) :14074-14079
[3]   MHC-environment interactions leading to type 1 diabetes: feasibility of an analysis of HLA DR-DQ alleles in relation to manifestation periods and dates of birth [J].
Badenhoop, K. ;
Kahles, H. ;
Seidl, C. ;
Kordonouri, O. ;
Lopez, E. R. ;
Walter, M. ;
Rosinger, S. ;
Ziegler, A. ;
Bohm, B. O. .
DIABETES OBESITY & METABOLISM, 2009, 11 :88-91
[4]   Network biology:: Understanding the cell's functional organization [J].
Barabási, AL ;
Oltvai, ZN .
NATURE REVIEWS GENETICS, 2004, 5 (02) :101-U15
[5]   Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes [J].
Barrett, Jeffrey C. ;
Clayton, David G. ;
Concannon, Patrick ;
Akolkar, Beena ;
Cooper, Jason D. ;
Erlich, Henry A. ;
Julier, Cecile ;
Morahan, Grant ;
Nerup, Jorn ;
Nierras, Concepcion ;
Plagnol, Vincent ;
Pociot, Flemming ;
Schuilenburg, Helen ;
Smyth, Deborah J. ;
Stevens, Helen ;
Todd, John A. ;
Walker, Neil M. ;
Rich, Stephen S. .
NATURE GENETICS, 2009, 41 (06) :703-707
[6]   Complete sequence and gene map of a human major histocompatibility complex [J].
Beck, S ;
Geraghty, D ;
Inoko, H ;
Rowen, L ;
Aguado, B ;
Bahram, S ;
Campbell, RD ;
Forbes, SA ;
Guillaudeux, T ;
Hood, L ;
Horton, R ;
Janer, M ;
Jasoni, C ;
Madan, A ;
Milne, S ;
Neville, M ;
Oka, A ;
Qin, S ;
Ribas-Despuig, G ;
Rogers, J ;
Shiina, T ;
Spies, T ;
Tamiya, G ;
Tashiro, H ;
Trowsdale, J ;
Vu, Q ;
Williams, L ;
Yamazaki, M .
NATURE, 1999, 401 (6756) :921-923
[7]   A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis [J].
Begovich, AB ;
Carlton, VEH ;
Honigberg, LA ;
Schrodi, SJ ;
Chokkalingam, AP ;
Alexander, HC ;
Ardlie, KG ;
Huang, QQ ;
Smith, AM ;
Spoerke, JM ;
Conn, MT ;
Chang, M ;
Chang, SYP ;
Saiki, RK ;
Catanese, JJ ;
Leong, DU ;
Garcia, VE ;
McAllister, LB ;
Jeffery, DA ;
Lee, AT ;
Batliwalla, F ;
Remmers, E ;
Criswell, LA ;
Seldin, MF ;
Kastner, DL ;
Amos, CI ;
Sninsky, JJ ;
Gregersen, PK .
AMERICAN JOURNAL OF HUMAN GENETICS, 2004, 75 (02) :330-337
[8]   A POLYMORPHIC LOCUS NEAR THE HUMAN INSULIN GENE IS ASSOCIATED WITH INSULIN-DEPENDENT DIABETES-MELLITUS [J].
BELL, GI ;
HORITA, S ;
KARAM, JH .
DIABETES, 1984, 33 (02) :176-183
[9]   Expression Profiling of Human Genetic and Protein Interaction Networks in Type 1 Diabetes [J].
Bergholdt, Regine ;
Brorsson, Caroline ;
Lage, Kasper ;
Nielsen, Jens Hoiriis ;
Brunak, Soren ;
Pociot, Flemming .
PLOS ONE, 2009, 4 (07)
[10]   Integrative analysis for finding genes and networks involved in diabetes and other complex diseases [J].
Bergholdt, Regine ;
Storling, Zenia M. ;
Lage, Kasper ;
Karlberg, E. Olof ;
Olason, Pall I. ;
Aalund, Mogens ;
Nerup, Jorn ;
Brunak, Soren ;
Workman, Christopher T. ;
Pociot, Flemming .
GENOME BIOLOGY, 2007, 8 (11)