Chemical basis for alkali cation selectivity in potassium-channel proteins

被引：16

作者：

Moczydlowski, E

机构：

[1] Yale Univ, Sch Med, Dept Pharmacol, New Haven, CT 06520 USA

[2] Yale Univ, Sch Med, Dept Cellular & Mol Physiol, New Haven, CT 06520 USA

来源：

CHEMISTRY & BIOLOGY | 1998年 / 5卷 / 11期

关键词：

D O I：

10.1016/S1074-5521(98)90288-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The determination of the crystal structure of a K+-selective channel protein from Streptomyces lividans reveals how the rapid movement of K+ across membranes is catalyzed by a large family of pore-forming proteins. Many features of the structure mirror hypotheses, predictions and models of K+ channels developed over the past four decades of functional analysis.

引用

收藏

页码：R291 / R301

页数：11

相关论文

共 49 条

[21] THE POTASSIUM PERMEABILITY OF A GIANT NERVE FIBRE [J].

HODGKIN, AL ;

KEYNES, RD .

JOURNAL OF PHYSIOLOGY-LONDON, 1955, 128 (01) :61-88

[22] Trapping of organic blockers by closing of voltage-dependent K+ channels - Evidence for a trap door mechanism of activation gating [J].

Holmgren, M ;

Smith, PL ;

Yellen, G .

JOURNAL OF GENERAL PHYSIOLOGY, 1997, 109 (05) :527-535

[23] Cloned potassium channels from eukaryotes and prokaryotes [J].

Jan, LY ;

Jan, YN .

ANNUAL REVIEW OF NEUROSCIENCE, 1997, 20 :91-123

[24] A NEW FAMILY OF OUTWARDLY RECTIFYING POTASSIUM CHANNEL PROTEINS WITH 2 PORE DOMAINS IN TANDEM [J].

KETCHUM, KA ;

JOINER, WJ ;

SELLERS, AJ ;

KACZMAREK, LK ;

GOLDSTEIN, SAN .

NATURE, 1995, 376 (6542) :690-695

[25] The interaction of Na+ and K+ in voltage-gated potassium channels -: Evidence for cation binding sites of different affinity [J].

Kiss, L ;

Immke, D ;

LoTurco, J ;

Korn, SJ .

JOURNAL OF GENERAL PHYSIOLOGY, 1998, 111 (02) :195-206

[26] PERMEATION SELECTIVITY BY COMPETITION IN A DELAYED RECTIFIER POTASSIUM CHANNEL [J].

KORN, SJ ;

IKEDA, SR .

SCIENCE, 1995, 269 (5222) :410-412

[27] PRIMARY STRUCTURE AND FUNCTIONAL EXPRESSION OF A MOUSE INWARD RECTIFIER POTASSIUM CHANNEL [J].

KUBO, Y ;

BALDWIN, TJ ;

JAN, YN ;

JAN, LY .

NATURE, 1993, 362 (6416) :127-133

[28] TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure [J].

Lesage, F ;

Guillemare, E ;

Fink, M ;

Duprat, F ;

Lazdunski, M ;

Romey, G ;

Barhanin, J .

EMBO JOURNAL, 1996, 15 (05) :1004-1011

[29] Gated access to the pore of a voltage-dependent K+ channel [J].

Liu, Y ;

Holmgren, M ;

Jurman, ME ;

Yellen, G .

NEURON, 1997, 19 (01) :175-184

[30] PORE LOOPS - AN EMERGING THEME IN ION-CHANNEL STRUCTURE [J].

MACKINNON, R .

NEURON, 1995, 14 (05) :889-892

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