Pd(II)-catalyzed cross-coupling of sp3 C-H bonds with sp2 and sp3 boronic acids using air as the oxidant

被引：432

作者：

Wang, Dong-Hui ^{[1
]}

Wasa, Masayuki ^{[1
]}

Giri, Ramesh ^{[1
]}

Yu, Jin-Quan ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 23期

关键词：

D O I：

10.1021/ja801355s

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

O-Methyl hydroxamic acids, readily available from carboxylic acids, are found to be extremely reactive for P-C-H activation by Pd(OAC)(2). This reactivity is exploited to develop the first example of cross-coupling sp(3) C-H bonds with sp(3) boronic acids. Air was shown to be a suitable stoichiometric oxidant for the catalytic oxidative coupling reaction. A biologically active natural product is readily converted to its novel analogues through this coupling reaction.

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页码：7190 / +

页数：3

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