学术探索
学术期刊
新闻热点
数据分析
智能评审

Acetogenins from annonaceae, inhibitors of mitochondrial complex I

被引：154
作者：
ZafraPolo, MC
Gonzalez, MC
Estornell, E
Sahpaz, S
Cortes, D
机构：
[1] UNIV VALENCIA, FAC FARM, DEPT FARMACOL FARMACOGNOSIA & FARMACODINAMIA, E-46100 BURJASSOT, VALENCIA, SPAIN
[2] UNIV VALENCIA, FAC FARM, DEPT BIOQUIM & BIOL MOLEC, E-46100 BURJASSOT, VALENCIA, SPAIN
来源：
PHYTOCHEMISTRY | 1996年 / 42卷 / 02期
关键词：
Annonaceae; linear and epoxy acetogenins; mono-; bis- and tri-tetrahydrofuran acetogenins; inhibitors of mitochondrial complex I;
D O I：
10.1016/0031-9422(95)00836-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
One-hundred and twenty-eight different linear, epoxy, mono-tetrahydrofuran, bis-tetrahydrofuran or tri-tetrahydrofuran acetogenins have been isolated from the Annonaceae. These new secondary metabolites are potent cytotoxic inhibitors of the mitochondrial NADH:ubiquinone oxidoreductase (complex I of the respiratory chain).
引用
收藏
页码：253 / 271
页数：19
相关论文
共 112 条
  • [1] ROLLINONE, A REVISION AND EXTENSION OF STRUCTURE
    ABREO, MJ
    SNEDEN, AT
    [J]. JOURNAL OF NATURAL PRODUCTS, 1990, 53 (04): : 983 - 985
  • [2] 4-HYDROXY-25-DESOXYNEOROLLINICIN, A NEW BISTETRAHYDROFURANOID ACETOGENIN FROM ROLLINIA-PAPILIONELLA
    ABREO, MJ
    SNEDEN, AT
    [J]. JOURNAL OF NATURAL PRODUCTS, 1989, 52 (04): : 822 - 828
  • [3] MODE OF ACTION OF BULLATACIN - A POTENT ANTITUMOR AND PESTICIDAL ANNONACEOUS ACETOGENIN
    AHAMMADSAHIB, KI
    HOLLINGWORTH, RM
    MCGOVREN, JP
    HUI, YH
    MCLAUGHLIN, JL
    [J]. LIFE SCIENCES, 1993, 53 (14) : 1113 - 1120
  • [4] GIGANTECIN - A NOVEL ANTIMITOTIC AND CYTOTOXIC ACETOGENIN, WITH NONADJACENT TETRAHYDROFURAN RINGS, FROM GONIOTHALAMUS-GIGANTEUS (ANNONACEAE)
    ALKOFAHI, A
    RUPPRECHT, JK
    LIU, YM
    CHANG, CJ
    SMITH, DL
    MCLAUGHLIN, JL
    [J]. EXPERIENTIA, 1990, 46 (05): : 539 - 541
  • [5] GONIOTHALAMICIN AND ANNONACIN - BIOACTIVE ACETOGENINS FROM GONIOTHALAMUS-GIGANTEUS (ANNONACEAE)
    ALKOFAHI, A
    RUPPRECHT, JK
    SMITH, DL
    CHANG, CJ
    MCLAUGHLIN, JL
    [J]. EXPERIENTIA, 1988, 44 (01): : 83 - 85
  • [6] [Anonymous], NAT PROD LETT
  • [7] ARAYA H, 1994, CHEM PHARM BULL, V42, P388, DOI 10.1248/cpb.42.388
  • [8] THE RELATIVE CONFIGURATION OF ACETOGENINS ISOLATED FROM ANNONA-SQUAMOSA - ANNONIN-I (SQUAMOCIN) AND ANNONIN-VI
    BORN, L
    LIEB, F
    LORENTZEN, JP
    MOESCHLER, H
    NONFON, M
    SOLLNER, R
    WENDISCH, D
    [J]. PLANTA MEDICA, 1990, 56 (03) : 312 - 316
  • [9] CAVE A, 1993, RECENT ADV PHYTOCHEM, V27, P167
  • [10] NOVEL ACETOGENINS FROM THE LEAVES OF ANNONA-PURPUREA
    CEPLEANU, F
    OHTANI, K
    HAMBURGER, M
    GUPTA, MP
    SOLIS, P
    HOSTETTMANN, K
    [J]. HELVETICA CHIMICA ACTA, 1993, 76 (03) : 1379 - 1388
12345678910