学术探索
学术期刊
新闻热点
数据分析
智能评审

Acetogenins from annonaceae, inhibitors of mitochondrial complex I

被引：154
作者：
ZafraPolo, MC
Gonzalez, MC
Estornell, E
Sahpaz, S
Cortes, D
机构：
[1] UNIV VALENCIA, FAC FARM, DEPT FARMACOL FARMACOGNOSIA & FARMACODINAMIA, E-46100 BURJASSOT, VALENCIA, SPAIN
[2] UNIV VALENCIA, FAC FARM, DEPT BIOQUIM & BIOL MOLEC, E-46100 BURJASSOT, VALENCIA, SPAIN
来源：
PHYTOCHEMISTRY | 1996年 / 42卷 / 02期
关键词：
Annonaceae; linear and epoxy acetogenins; mono-; bis- and tri-tetrahydrofuran acetogenins; inhibitors of mitochondrial complex I;
D O I：
10.1016/0031-9422(95)00836-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
One-hundred and twenty-eight different linear, epoxy, mono-tetrahydrofuran, bis-tetrahydrofuran or tri-tetrahydrofuran acetogenins have been isolated from the Annonaceae. These new secondary metabolites are potent cytotoxic inhibitors of the mitochondrial NADH:ubiquinone oxidoreductase (complex I of the respiratory chain).
引用
收藏
页码：253 / 271
页数：19
相关论文
共 112 条
  • [41] Gu Zhe-Ming, 1994, Natural Toxins, V2, P49, DOI 10.1002/nt.2620020202
  • [42] NEW CYTOTOXIC ANNONACEOUS ACETOGENINS - BULLATANOCIN AND CIS-BULLATANOCINONE AND TRANS-BULLATANOCINONE, FROM ANNONA-BULLATA (ANNONACEAE)
    GU, ZM
    FANG, XP
    RIESER, MJ
    HUI, YH
    MIESBAUER, LR
    SMITH, DL
    WOOD, KV
    MCLAUGHLIN, JL
    [J]. TETRAHEDRON, 1993, 49 (04) : 747 - 754
  • [43] GONIONENIN - A NEW CYTOTOXIC ANNONACEOUS ACETOGENIN FROM GONIOTHALAMUS-GIGANTEUS AND THE CONVERSION OF MONO-THF ACETOGENINS TO BIS-THF ACETOGENINS
    GU, ZM
    FANG, XP
    ZENG, L
    SONG, R
    NG, JH
    WOOD, KV
    SMITH, DL
    MCLAUGHLIN, JL
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1994, 59 (12) : 3472 - 3479
  • [44] 30-HYDROXYBULLATACINONE, 31-HYDROXYBULLATACINONE, AND 32-HYDROXYBULLATACINONE - BIOACTIVE TERMINALLY HYDROXYLATED ANNONACEOUS ACETOGENINS FROM ANNONA-BULLATA
    GU, ZM
    FANG, XP
    MIESBAUER, LR
    SMITH, DL
    MCLAUGHLIN, JL
    [J]. JOURNAL OF NATURAL PRODUCTS, 1993, 56 (06): : 870 - 876
  • [45] GONIOCIN FROM GONIOTHALAMUS-GIGANTEUS - THE FIRST TRI-THF ANNONACEOUS ACETOGENIN
    GU, ZM
    FANG, XP
    ZENG, L
    MCLAUGHLIN, JL
    [J]. TETRAHEDRON LETTERS, 1994, 35 (30) : 5367 - 5368
  • [46] GU ZM, 1993, HETEROCYCLES, V36, P2221
  • [47] NOVEL CYTOTOXIC ANNONACEOUS ACETOGENINS - (2,4-CIS AND TRANS)-BULLADECINONES FROM ANNONA-BULLATA (ANNONACEAE)
    GU, ZM
    FANG, XP
    ZENG, L
    KOZLOWSKI, JF
    MCLAUGHLIN, JL
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1994, 4 (03) : 473 - 478
  • [48] GU ZM, 1995, HETEROCYCLES, V41, P229
  • [49] STRUCTURAL STUDIES OF POLYHYDROXYBIS(TETRAHYDROFURAN)ACETOGENINS FROM ANNONA-SQUAMOSA USING THE COMBINATION OF CHEMICAL DERIVATIZATION AND PRECURSOR-ION SCANNING MASS-SPECTROMETRY
    HIRAYAMA, K
    AKASHI, S
    YUJI, R
    NIITSU, U
    FUJIMOTO, Y
    [J]. ORGANIC MASS SPECTROMETRY, 1993, 28 (12): : 1516 - 1524
  • [50] ACETOGENINS FROM ROOT BARK OF UVARIA-NARUM
    HISHAM, A
    PIETERS, LAC
    CLAEYS, M
    VANDENHEUVEL, H
    ESMANS, E
    DOMMISSE, R
    VLIETINCK, AJ
    [J]. PHYTOCHEMISTRY, 1991, 30 (07) : 2373 - 2377
12345678910