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Acetogenins from annonaceae, inhibitors of mitochondrial complex I

被引：154
作者：
ZafraPolo, MC
Gonzalez, MC
Estornell, E
Sahpaz, S
Cortes, D
机构：
[1] UNIV VALENCIA, FAC FARM, DEPT FARMACOL FARMACOGNOSIA & FARMACODINAMIA, E-46100 BURJASSOT, VALENCIA, SPAIN
[2] UNIV VALENCIA, FAC FARM, DEPT BIOQUIM & BIOL MOLEC, E-46100 BURJASSOT, VALENCIA, SPAIN
来源：
PHYTOCHEMISTRY | 1996年 / 42卷 / 02期
关键词：
Annonaceae; linear and epoxy acetogenins; mono-; bis- and tri-tetrahydrofuran acetogenins; inhibitors of mitochondrial complex I;
D O I：
10.1016/0031-9422(95)00836-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
One-hundred and twenty-eight different linear, epoxy, mono-tetrahydrofuran, bis-tetrahydrofuran or tri-tetrahydrofuran acetogenins have been isolated from the Annonaceae. These new secondary metabolites are potent cytotoxic inhibitors of the mitochondrial NADH:ubiquinone oxidoreductase (complex I of the respiratory chain).
引用
收藏
页码：253 / 271
页数：19
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