Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (αvβ3) antagonists

被引：28

作者：

Keenan, RM ^{[1
]}

Miller, WH ^{[1
]}

Lago, MA ^{[1
]}

Ali, FE ^{[1
]}

Bondinell, WE ^{[1
]}

Callahan, JF ^{[1
]}

Calvo, RR ^{[1
]}

Cousins, RD ^{[1
]}

Hwang, SM ^{[1
]}

Jakas, DR ^{[1
]}

Ku, TW ^{[1
]}

Kwon, C ^{[1
]}

Nguyen, TT ^{[1
]}

Reader, VA ^{[1
]}

Rieman, DJ ^{[1
]}

Ross, ST ^{[1
]}

Takata, DT ^{[1
]}

Uzinskas, IN ^{[1
]}

Yuan, CCK ^{[1
]}

Smith, BR ^{[1
]}

机构：

[1] SmithKline Beecham Pharmaceut, Div Res & Dev, Collegeville, PA 19426 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 22期

关键词：

D O I：

10.1016/S0960-894X(98)00555-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In a 3-oxo-1,4-benzodiazepine-2-acetic acid series of vitronectin receptor (alpha v beta 3) antagonists containing a benzimidazole as a novel arginine mimetic, we examined the effects of benzimidazole modifications and amide substitutions on both activity and pharmacokinetics. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：3165 / 3170

页数：6

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