Palladium-Catalyzed Approach to Primary Amides Using Nongaseous Precursors

被引：61

作者：

Nielsen, Dennis U. ^{[1
]}

Taaning, Rolf H. ^{[1
]}

Lindhardt, Anders T. ^{[1
]}

Gogsig, Thomas M. ^{[1
]}

Skrydstrup, Troels ^{[1
]}

机构：

[1] Aarhus Univ, Dept Chem, Interdisciplinary Nanosci Ctr, Ctr Insoluble Prot Struct inSPIN, DK-8000 Aarhus C, Denmark

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 16期

基金：

新加坡国家研究基金会;

关键词：

CARBON-MONOXIDE SOURCE; ARYL HALIDES; ATMOSPHERIC-PRESSURE; EX-SITU; AMINOCARBONYLATION; CARBONYLATION; CO; AMMONIA; BROMIDES; ELECTROPHILES;

D O I：

10.1021/ol201808y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple protocol Is reported for the preparation of primary aryl amides under Pd-catalyzed carbonylation chemistry applying a two-chamber system with crystalline and nontransition metal based sources of carbon monoxide and ammonia. The method is suitable for the synthesis of a number of primary amides with good functional group tolerance. Incorporation of (CO)-C-13 Into the primary amide group was also found to be effective making this approach useful for accessing carbon isotope labeled derivatives.

引用

页码：4454 / 4457

页数：4

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