Heteroaromatic Sulfonates and Phosphates as Electrophiles in Iron-Catalyzed Cross-Couplings

被引：79

作者：

Gogsig, Thomas M.

Lindhardt, Anders T.

Skrydstrup, Troels ^{[1
]}

机构：

[1] Aarhus Univ, Ctr Insoluble Prot Struct inSPIN, Dept Chem, DK-8000 Aarhus C, Denmark

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 21期

基金：

新加坡国家研究基金会;

关键词：

ARYL GRIGNARD-REAGENTS; PYRIDINE N-OXIDES; SUZUKI-MIYAURA; PYRIMIDINE-DERIVATIVES; ALKENYL PHOSPHATES; DIRECT ARYLATION; ENOL PHOSPHATES; TOSYLATES; FUNCTIONALIZATION; AMINATION;

D O I：

10.1021/ol901975u

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Employment of heteroaromatic tosylates and phosphates as suitable electrophiles in iron-catalyzed cross-coupling reactions with alkyl Grignard reagents is reported. These reactions are performed at low temperature allowing good functional group tolerance and full conversion is achieved within minutes. In addition, an aryl-aryl cross-coupling utilizing a heteroaryl sulfamate electrophile is reported.

引用

收藏

页码：4886 / 4888

页数：3

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