The ins and outs of signalling

被引:146
作者
Downward, J [1 ]
机构
[1] Imperial Canc Res Fund, Signal Transduct Lab, London WC2A 3PX, England
关键词
D O I
10.1038/35081138
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The study of how cells communicate impinges on all aspects of biology, from development to disease. At first glance it's a horrendously complicated business, but some simple themes are emerging.
引用
收藏
页码:759 / 762
页数:4
相关论文
共 25 条
[21]   Understanding Ras: 'it ain't over 'til it's over' [J].
Shields, JM ;
Pruitt, K ;
McFall, A ;
Shaub, A ;
Der, CJ .
TRENDS IN CELL BIOLOGY, 2000, 10 (04) :147-154
[22]   The sequence of the human genome [J].
Venter, JC ;
Adams, MD ;
Myers, EW ;
Li, PW ;
Mural, RJ ;
Sutton, GG ;
Smith, HO ;
Yandell, M ;
Evans, CA ;
Holt, RA ;
Gocayne, JD ;
Amanatides, P ;
Ballew, RM ;
Huson, DH ;
Wortman, JR ;
Zhang, Q ;
Kodira, CD ;
Zheng, XQH ;
Chen, L ;
Skupski, M ;
Subramanian, G ;
Thomas, PD ;
Zhang, JH ;
Miklos, GLG ;
Nelson, C ;
Broder, S ;
Clark, AG ;
Nadeau, C ;
McKusick, VA ;
Zinder, N ;
Levine, AJ ;
Roberts, RJ ;
Simon, M ;
Slayman, C ;
Hunkapiller, M ;
Bolanos, R ;
Delcher, A ;
Dew, I ;
Fasulo, D ;
Flanigan, M ;
Florea, L ;
Halpern, A ;
Hannenhalli, S ;
Kravitz, S ;
Levy, S ;
Mobarry, C ;
Reinert, K ;
Remington, K ;
Abu-Threideh, J ;
Beasley, E .
SCIENCE, 2001, 291 (5507) :1304-+
[23]   Protein interaction maps for model organisms [J].
Walhout, AJM ;
Vidal, M .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2001, 2 (01) :55-62
[24]   Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals [J].
Whitmarsh, AJ ;
Davis, RJ .
TRENDS IN BIOCHEMICAL SCIENCES, 1998, 23 (12) :481-485
[25]   Perspective: The insulin signaling system - A common link in the pathogenesis of type 2 diabetes [J].
Withers, DJ ;
White, M .
ENDOCRINOLOGY, 2000, 141 (06) :1917-1921