The sickle cell trait is associated with enhanced immunoglobulin G antibody responses to Plasmodium falciparum variant surface antigens

被引:56
作者
Cabrera, G
Cot, M
Migot-Nabias, F
Kremsner, PG
Deloron, P
Luty, AJF
机构
[1] Univ Tubingen, Inst Trop Med, Dept Parasitol, Tubingen, Germany
[2] Albert Schweitzer Hosp, Med Res Unit, Lambarene, Gabon
[3] Ctr Int Rech Med, Unite Parasitol Med, Franceville, Gabon
[4] Fac Pharm, Inst Dev Res, Paris, France
关键词
D O I
10.1086/429832
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The sickle cell trait (HbAS) protects against severe Plasmodium falciparum malaria in young African children. We investigated the extent of the association between HbAS and antibodies directed to parasite-derived variant surface antigens (VSAs) on the membrane of infected erythrocytes. We measured immunoglobulin G (IgG) responses with specificity for VSAs of 2 heterologous parasite isolates in 458 Gabonese children aged between 6 months and 11 years. Logistic regression analyses showed a highly significant independent association (P<.001) between carriage of HbAS and the presence of IgG anti-VSA responses; this association was related specifically to IgG1 and IgG4 subclasses in the anti-VSA profile. IgG2 and IgG3 anti-VSA responses were both independently associated with older age, consistent with the pattern observed in semi-immune adults. The results imply that enhanced levels of cross-reactive anti-VSA responses in children with HbAS may be intimately associated with the protection they have against malaria.
引用
收藏
页码:1631 / 1638
页数:8
相关论文
共 54 条
  • [11] Does the mechanism of protection from falciparum malaria by red cell genetic disorders involve a switch to a balanced T(H)1/T(H)2 cytokine production mode?
    Bayoumi, RAL
    [J]. MEDICAL HYPOTHESES, 1997, 48 (01) : 11 - 17
  • [12] Plasmodium falciparum infections are associated with agglutinating antibodies to parasite-infected erythrocyte surface antigens among healthy Kenyan children
    Bull, PC
    Lowe, BS
    Kaleli, N
    Njuga, F
    Kortok, M
    Ross, A
    Ndungu, F
    Snow, RW
    Marsh, K
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2002, 185 (11) : 1688 - 1691
  • [13] Parasite antigens on the infected red cell surface are targets for naturally acquired immunity to malaria
    Bull, PC
    Lowe, BS
    Kortok, M
    Molyneux, CS
    Newbold, CI
    Marsh, K
    [J]. NATURE MEDICINE, 1998, 4 (03) : 358 - 360
  • [14] Mechanisms of disease - Pathogenesis and treatment of sickle cell disease
    Bunn, HF
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1997, 337 (11) : 762 - 769
  • [15] Immunoglobulin G isotype responses to variant surface antigens of Plasmodium falciparum in healthy gabonese adults and children during and after successive malaria attacks
    Cabrera, G
    Yone, C
    Tebo, AE
    van Aaken, J
    Lell, B
    Kremsner, PG
    Luty, AJF
    [J]. INFECTION AND IMMUNITY, 2004, 72 (01) : 284 - 294
  • [16] PLASMODIUM-FALCIPARUM ERYTHROCYTE ROSETTING IS MEDIATED BY PROMISCUOUS LECTIN-LIKE INTERACTIONS
    CARLSON, J
    WAHLGREN, M
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 176 (05) : 1311 - 1317
  • [17] HUMAN CEREBRAL MALARIA - ASSOCIATION WITH ERYTHROCYTE ROSETTING AND LACK OF ANTI-ROSETTING ANTIBODIES
    CARLSON, J
    HELMBY, H
    HILL, AVS
    BREWSTER, D
    GREENWOOD, BM
    WAHLGREN, M
    [J]. LANCET, 1990, 336 (8729) : 1457 - 1460
  • [18] Plasmodium falciparum infection elicits both variant- specific and cross-reactive antibodies against variant surface antigens
    Chattopadhyay, R
    Sharma, A
    Srivastava, VK
    Pati, SS
    Sharma, SK
    Das, BS
    Chitnis, CE
    [J]. INFECTION AND IMMUNITY, 2003, 71 (02) : 597 - 604
  • [19] Deloron P, 1997, CLIN EXP IMMUNOL, V110, P212
  • [20] IMMUNOGLOBULIN-M AND IMMUNOGLOBULIN-G ANTIBODY-RESPONSES TO PLASMODIUM-FALCIPARUM GLUTAMATE-RICH PROTEIN - CORRELATION WITH CLINICAL IMMUNITY IN GAMBIAN CHILDREN
    DZIEGIEL, M
    ROWE, P
    BENNETT, S
    ALLEN, SJ
    OLERUP, O
    GOTTSCHAU, A
    BORRE, M
    RILEY, EM
    [J]. INFECTION AND IMMUNITY, 1993, 61 (01) : 103 - 108