Embryotoxicity and teratogenicity studies of poly (DL-Lactide-co-Glycolide) microspheres incorporated tetanus toxoid in Wistar rats

被引：5

作者：

Chandrasekaran, R ^{[1
]}

Giri, DK ^{[1
]}

Chaudhury, MR ^{[1
]}

机构：

[1] NATL INST IMMUNOL,DIV TOXICOL,NEW DELHI 110067,INDIA

来源：

HUMAN & EXPERIMENTAL TOXICOLOGY | 1996年 / 15卷 / 04期

关键词：

biodegradable polymer; vaccine; tetanus toroid; teratogenicity;

D O I：

10.1177/096032719601500411

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Tetanus Toroid loaded biodegradable microspheres (MTT) (poly (DL-Lactide-co-Glycolide) were administered intramuscularly to pregnant Wistar rats from Days 6 to 15 of gestation, at 1, 5 and 10-times the human equivalent dose of TT. Developmental defects in relation to soft tissues and skeleton, weight and sex of live pups and early fetal deaths from treated and control rats were analysed. The findings in treatment groups were comparable to those in the controls. These observations show that MTT was safe for pregnant rats and developing pups.

引用

页码：349 / 351

页数：3

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