Mitochondrial DNA depletion, near-fatal metabolic acidosis, and liver failure in an HIV-infected child treated with combination antiretroviral therapy

被引：34

作者：

Church, JA

Mitchell, WG

Gonzalez-Gomez, I

Christensen, J

Vu, TH

Dimauro, S

Boles, RG

机构：

[1] Childrens Hosp Los Angeles, Clin Immunol & Allergy, Dept Pediat, Los Angeles, CA 90054 USA

[2] Childrens Hosp Los Angeles, Dept Lab Med, Los Angeles, CA 90054 USA

[3] Univ So Calif, Sch Med, Los Angeles, CA USA

[4] Univ Nevada, Sch Med, Dept Internal Med, Las Vegas, NV 89154 USA

[5] Columbia Univ, Coll Phys & Surg, Dept Neurol, New York, NY USA

来源：

JOURNAL OF PEDIATRICS | 2001年 / 138卷 / 05期

关键词：

D O I：

10.1067/mpd.2001.112653

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

A child with controlled human immunodeficiency virus infection presented with neurologic deterioration, lactic acidosis, and organic aciduria. Muscle biopsy revealed abnormal mitochondrial (mt) morphology, reduced mt enzyme activities, and mtDNA depletion. After adjustment of antiretroviral therapy to a regimen free of nucleoside analogs, marked improvement was seen in clinical status and mt abnormalities.

引用

页码：748 / 751

页数：4

共 11 条

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