The analysis of Neisseria meningitidis proteomes:: Reference maps and their applications

被引:12
作者
Bernardini, Giulia [1 ]
Braconi, Daniela [1 ]
Santucci, Annalisa [1 ]
机构
[1] Univ Siena, Dipartimento Biol Mol, I-53100 Siena, Italy
关键词
microevolution; Neisseria meningitidis; reference map; two-dimensional gel electrophoresis;
D O I
10.1002/pmic.200700094
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Neisseria meningitidis is an encapsulated Gram-negative bacterium responsible for significant morbidity and mortality worldwide. The availability of meningococcal genome sequences in combination with the rapid growth of proteomic techniques and other high-throughput methods, provided new approaches to the analysis of bacterial system biology. This review considers the meningococcal reference maps so far published as a starting point aimed to elucidate bacterial physiology and pathogenicity, paying particular attention to proteins with potential vaccine and diagnostic applications.
引用
收藏
页码:2933 / 2946
页数:14
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