miRNomics - The bioinformatics of microRNA genes

被引：47

作者：

Ghosh, Zhumur

Chakrabarti, Jayprokas

Mallick, Bibekanand

机构：

[1] Indian Assoc Cultivat Sci, Computat Biol Grp, Kolkata 700032, W Bengal, India

[2] Gyanxet, Kolkata 700064, W Bengal, India

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2007年 / 363卷 / 01期

关键词：

miRNA; bioinformatics; microRNA; cancer; noncoding RNA; stem cell; apoptosis; miRNA target;

D O I：

10.1016/j.bbrc.2007.08.030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs (miRNAs) are tiny genetic rheostats in plants, animals, and viruses, regulating the expression of messenger RNAs by targeting transcripts for cleavage or translational repression. Their regulatory impact is even more pervasive as a potential therapeutic tool. Since inception, computational methods have been an invaluable tool complementing experimental approaches. Here, we outline miRNA-bioinformatics highlighting the biological and therapeutic repertoire of miRNAs, in silico prediction of miRNA genes and their targets, along with a glimpse of the bioinformatic challenges that lie ahead. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：6 / 11

页数：6

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