Hsf1p and Msn2/4p cooperate in the expression of Saccharomyces cerevisiae genes HSP26 and HSP104 in a gene- and stress type-dependent manner

被引：101

作者：

Amorós, M

Estruch, F ^{[1
]}

机构：

[1] Univ Valencia, Fac Ciencias Biol, Dept Bioquim & Biol Mol, E-46100 Burjassot, Spain

[2] Inst Agroquim & Tecnol Alimentos, CSIC, Dept Biotecnol, Burjassot, Spain

来源：

MOLECULAR MICROBIOLOGY | 2001年 / 39卷 / 06期

关键词：

D O I：

10.1046/j.1365-2958.2001.02339.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Saccharomyces cerevisiae possesses several transcription factors involved in the transcriptional activation of stress-induced genes. Among them, the heat shock factor (Hsf1p) and the zinc finger proteins of the general stress response (Msn2p and Msn4p) have been shown to play a major role in stress protection. Some heat shock protein (HSP) genes contain both heat shock elements (HSEs) and stress response elements (STREs), suggesting the involvement of both transcription factors in their regulation. Analysis of the stress-induced expression of two of these genes, HSP26 and HSP104, reveals that the contribution of Hsf1p and Msn2/4p is different depending on the gene and the stress condition.

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收藏

页码：1523 / 1532

页数：10

相关论文

共 35 条

[21] STRESS SIGNALING IN YEAST [J].

RUIS, H ;

SCHULLER, C .

BIOESSAYS, 1995, 17 (11) :959-965

[22] Heat shock element architecture is an important determinant in the temperature and transactivation domain requirements for heat shock transcription factor [J].

Santoro, N ;

Johansson, N ;

Thiele, DJ .

MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (11) :6340-6352

[23] Multiple independent regulatory pathways control UBI4 expression after heat shock in Saccharomyces cerevisiae [J].

Simon, JR ;

Treger, JM ;

McEntee, K .

MOLECULAR MICROBIOLOGY, 1999, 31 (03) :823-832

[24] A MUTATION IN THE YEAST HEAT-SHOCK FACTOR GENE CAUSES TEMPERATURE-SENSITIVE DEFECTS IN BOTH MITOCHONDRIAL PROTEIN IMPORT AND THE CELL-CYCLE [J].

SMITH, BJ ;

YAFFE, MP .

MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (05) :2647-2655

[25] YEAST HEAT-SHOCK FACTOR CONTAINS SEPARABLE TRANSIENT AND SUSTAINED RESPONSE TRANSCRIPTIONAL ACTIVATORS [J].

SORGER, PK .

CELL, 1990, 62 (04) :793-805

[26] HEAT-SHOCK FACTOR AND THE HEAT-SHOCK RESPONSE [J].

SORGER, PK .

CELL, 1991, 65 (03) :363-366

[27] HEAT-SHOCK FACTOR IS REGULATED DIFFERENTLY IN YEAST AND HELA-CELLS [J].

SORGER, PK ;

LEWIS, MJ ;

PELHAM, HRB .

NATURE, 1987, 329 (6134) :81-84

[28] YEAST HEAT-SHOCK FACTOR IS AN ESSENTIAL DNA-BINDING PROTEIN THAT EXHIBITS TEMPERATURE-DEPENDENT PHOSPHORYLATION [J].

SORGER, PK ;

PELHAM, HRB .

CELL, 1988, 54 (06) :855-864

[29] TRANSCRIPTIONAL DEREPRESSION OF THE SACCHAROMYCES-CEREVISIAE HSP26 GENE DURING HEAT-SHOCK [J].

SUSEK, RE ;

LINDQUIST, S .

MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (12) :6362-6373

[30] HEAT-SHOCK TRANSCRIPTION FACTOR ACTIVATES YEAST METALLOTHIONEIN GENE-EXPRESSION IN RESPONSE TO HEAT AND GLUCOSE STARVATION VIA DISTINCT SIGNALING PATHWAYS [J].

TAMAI, KT ;

LIU, XD ;

SILAR, P ;

SOSINOWSKI, T ;

THIELE, DJ .

MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (12) :8155-8165

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