Cytotoxicity of ionic liquids and precursor compounds towards human cell line HeLa

被引:174
作者
Wang, Xuefeng [1 ]
Ohlin, C. Andre
Lu, Qinghua
Fei, Zhaofu
Hu, Jun
Dyson, Paul J.
机构
[1] Shanghai Jiao Tong Univ, Sch Chem & Chem Technol, Shanghai 200240, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Shanghai 200240, Peoples R China
[3] Swiss Fed Inst Technol, Inst Sci & Ingn Chim, Lab Organomet & Med Chem, CH-1015 Lausanne, Switzerland
关键词
D O I
10.1039/b704503d
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The toxicity of ethyl-, butyl-, octyl-, benzyl-, and allyl-substituted 1-alkyl-3-methylimidazolium, alkylpyridinium, N-alkyl-N, N-dimethyl-N-(2-hydroxyethyl) ammonium (choline derivatives) and alkyl-triethylammonium salts towards HeLa cells has been studied. The relative toxicities have been determined in the presence and absence of foetal bovine serum using an MTT assay after 24 and 48 h, and attempts to determine possible sources of the observed toxicity investigated using microscopy and by measuring the intracellular calcium concentration, presence of reactive oxygen species and mitochondrial membrane potential in cells exposed to 1-ethyl-3-methylimidazolium tetrafluoroborate.
引用
收藏
页码:1191 / 1197
页数:7
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