Catalytic asymmetric fluorination comes of age

被引：176

作者：

Brunet, Vincent A. ^{[1
]}

O'Hagan, David ^{[1
]}

机构：

[1] Univ St Andrews, Sch Chem, Biomed Sci Ctr, St Andrews KY16 9ST, Fife, Scotland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 07期

基金：

英国工程与自然科学研究理事会;

关键词：

asymmetric catalysis; electrophilic substitution; fluorinated substituents; fluorination;

D O I：

10.1002/anie.200704700

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Gimme an F: Ever since the first asymmetricfluorination reagents were reported in 1988, the enantioselective introduction of a C-F bond at a stereogenicc enter has emerged as a major objective in organic chemistry. Newly published results on the enantioselective fluorination of malonates (see scheme) are put into context in this Highlight. NFSI = N-fluorodibenzenesulfonimide. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1179 / 1182

页数：4

共 38 条

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