Linear assemblies of magnetic nanoparticles as MRI contrast agents

被引:135
作者
Corr, Serena A. [1 ]
Byrne, Stephen J. [1 ]
Tekoriute, Renata [1 ]
Meledandri, Carla J. [2 ]
Brougham, Dermot F. [2 ]
Lynch, Marina [3 ]
Kerskens, Christian [3 ]
O'Dwyer, Laurence [3 ]
Gun'ko, Yurii K. [1 ]
机构
[1] Univ Dublin, Trinity Coll, Sch Chem, Dublin 2, Ireland
[2] Dublin City Univ, Sch Chem Sci, Natl Inst Cellular Biotechnol, Dublin 9, Ireland
[3] Univ Dublin, Inst Neurosci, Dublin 2, Ireland
关键词
D O I
10.1021/ja710172z
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Using a one-step procedure we have prepared magnetic fluids comprising of polyelectrolyte stabilized magnetite nanoparticles. These nanocomposites are comprised of linear, chain-like assemblies of magnetic nanoparticles, which can be aligned in parallel arrays by an external magnetic field. We have shown the potential use of these materials as contrast agents by measuring their MR response in live rats. The new magnetic fluids have demonstrated good biocompatibility and potential for in vivo MRI diagnostics.
引用
收藏
页码:4214 / +
页数:3
相关论文
共 26 条
[1]   Selective treatment of neoplastic cells using ferritin-mediated electromagnetic hyperthermia [J].
Babincová, M ;
Leszczynska, D ;
Sourivong, P ;
Babinec, P .
MEDICAL HYPOTHESES, 2000, 54 (02) :177-179
[2]   Controlled clustering of superparamagnetic nanoparticles using block copolymers: Design of new contrast agents for magnetic resonance imaging [J].
Berret, JF ;
Schonbeck, N ;
Gazeau, F ;
El Kharrat, D ;
Sandre, O ;
Vacher, A ;
Airiau, M .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (05) :1755-1761
[3]   Mechanics of semiflexible chains formed by poly(ethylene glycol)-linked paramagnetic particles [J].
Biswal, SL ;
Gast, AP .
PHYSICAL REVIEW E, 2003, 68 (02) :9
[4]   A SYNAPTIC MODEL OF MEMORY - LONG-TERM POTENTIATION IN THE HIPPOCAMPUS [J].
BLISS, TVP ;
COLLINGRIDGE, GL .
NATURE, 1993, 361 (6407) :31-39
[5]   Magnetic nanoparticle assemblies on denatured DNA show unusual magnetic relaxivity and potential applications for MRI [J].
Byrne, SJ ;
Corr, SA ;
Gun'ko, YK ;
Kelly, JM ;
Brougham, DF ;
Ghosh, S .
CHEMICAL COMMUNICATIONS, 2004, (22) :2560-2561
[6]   Tuning the response of magnetic suspensions [J].
Chen, M ;
Sun, L ;
Bonevich, JE ;
Reich, DH ;
Chien, CL ;
Searson, PC .
APPLIED PHYSICS LETTERS, 2003, 82 (19) :3310-3312
[7]   Magnetic-fluorescent nanocomposites for biomedical multitasking [J].
Corr, Serena A. ;
O' Byrne, Aisling ;
Gun'ko, Yurii K. ;
Ghosh, Swapankumar ;
Brougham, Dermot F. ;
Mitchell, Siobhan ;
Volkov, Yuri ;
Prina-Mello, Adriele .
CHEMICAL COMMUNICATIONS, 2006, (43) :4474-4476
[8]   Permanently linked monodisperse paramagnetic chains [J].
Furst, EM ;
Suzuki, C ;
Fermigier, M ;
Gast, AP .
LANGMUIR, 1998, 14 (26) :7334-7336
[9]   INTRACELLULAR HYPERTHERMIA - BIOPHYSICAL APPROACH TO CANCER-TREATMENT VIA INTRACELLULAR TEMPERATURE AND BIOPHYSICAL ALTERATIONS [J].
GORDON, RT ;
HINES, JR ;
GORDON, D .
MEDICAL HYPOTHESES, 1979, 5 (01) :83-102
[10]   Self-assembled magnetic nanowires made irreversible by polymer bridging [J].
Goubault, C ;
Leal-Calderon, F ;
Viovy, JL ;
Bibette, J .
LANGMUIR, 2005, 21 (09) :3725-3729