Circulating microRNAs as novel and sensitive biomarkers of acute myocardial Infarction

被引：110

作者：

Li, Chuanwei ^{[1
,2
]}

Pei, Fang ^{[1
,2
]}

Zhu, Xiaoshan ^{[3
]}

Duan, Dayue D. ^{[2
,4
]}

Zeng, Chunyu ^{[1
,2
]}

机构：

[1] Third Mil Med Univ, Dept Cardiol, Daping Hosp, Chongqing 400042, Peoples R China

[2] Chongqing Inst Cardiol, Chongqing, Peoples R China

[3] Univ Nevada, Dept Elect & Biomed Engn, Reno, NV 89557 USA

[4] Univ Nevada, Sch Med, Dept Pharmacol, Cardiovasc Phen Lab, Reno, NV 89557 USA

来源：

CLINICAL BIOCHEMISTRY | 2012年 / 45卷 / 10-11期

基金：

中国国家自然科学基金;

关键词：

MicroRNA; Biomarker; Circulating; Acute myocardial infarction; PERIPHERAL-BLOOD; PLASMA; IDENTIFICATION; BIOGENESIS; DIAGNOSIS; MECHANISM; EXPORT; SERUM; MICROVESICLES; CHOLESTEROL;

D O I：

10.1016/j.clinbiochem.2012.04.013

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

100118 [医学信息学]; 100208 [临床检验诊断学];

摘要：

Coronary artery disease and acute myocardial infarction (AMI) are the leading causes of death for both men and women. Serum cardiac-specific troponin level is now used for the "early" diagnosis of AMI. However, due to the "delayed" release of troponin, an earlier, more sensitive and specific biomarker is urgently demanded to further reduce AMI mortality. Recent studies have found that circulating microRNAs (miRNAs) are closely linked to myocardial injury. Due to the cell-specific physiological functions and the stability of miRNAs in plasma, serum, and urine, they are emerging as sensitive biomarkers of AMI. This review summarizes the latest insights into the identification and potential application of plasma and serum miRNAs as novel biomarkers for diagnosis and prognosis of AMI. (C) 2012 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

引用

页码：727 / 732

页数：6

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