The Polycomb complex PRC2 and its mark in life

被引：2442

作者：

Margueron, Raphael ^{[2
,3
,4
]}

Reinberg, Danny ^{[1
]}

机构：

[1] NYU, Sch Med, Dept Biochem, Howard Hughes Med Inst, New York, NY 10016 USA

[2] Inst Curie, F-75005 Paris, France

[3] CNRS, UMR3215, F-75005 Paris, France

[4] INSERM, U934, F-75005 Paris, France

来源：

NATURE | 2011年 / 469卷 / 7330期

基金：

美国国家卫生研究院;

关键词：

EMBRYONIC STEM-CELLS; H3; LYSINE; 27; METHYLTRANSFERASE GENE EZH2; RNA-POLYMERASE-II; TARGET GENES; CHROMATIN-STRUCTURE; GROUP PROTEINS; DEVELOPMENTAL REGULATORS; DNA METHYLATION; NONCODING RNA;

D O I：

10.1038/nature09784

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Polycomb group proteins maintain the gene-expression pattern of different cells that is set during early development by regulating chromatin structure. In mammals, two main Polycomb group complexes exist - Polycomb repressive complex 1 (PRC1) and 2 (PRC2). PRC1 compacts chromatin and catalyses the monoubiquitylation of histone H2A. PRC2 also contributes to chromatin compaction, and catalyses the methylation of histone H3 at lysine 27. PRC2 is involved in various biological processes, including differentiation, maintaining cell identity and proliferation, and stem-cell plasticity. Recent studies of PRC2 have expanded our perspectives on its function and regulation, and uncovered a role for non-coding RNA in the recruitment of PRC2 to target genes.

引用

页码：343 / 349

页数：7

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