Where is APC going?

被引：51

作者：

Mimori-Kiyosue, Y

Tsukita, S ^{[1
]}

机构：

[1] Kyoto Univ, Fac Med, Dept Cell Biol, Sakyo Ku, Kyoto 6068315, Japan

[2] KAN Res Inst, Shimogyo Ku, Kyoto 6008815, Japan

[3] Japan Sci & Technol Corp, Tsukita Cell Axis Project, Shimogyo Ku, Kyoto 6008813, Japan

来源：

JOURNAL OF CELL BIOLOGY | 2001年 / 154卷 / 06期

关键词：

APC; microtubule; cytoskeletons; Wnt; beta-catenin;

D O I：

10.1083/jcb.200106113

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Adenomatous polyposis coli (APC) protein has been thought to function as a tumor suppressor through its involvement in the Wnt/beta -catenin signaling pathway. However, its connections to the cytoskeleton and microtubules. in particular are becoming apparent, and the discovery of these new functions for APC is leading to a reevaluation of its role not only in tumorigenesis, but also in normal physiology.

引用

收藏

页码：1105 / 1109

页数：5

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