Diagnostics of single base-mismatch DNA hybridization on gold nanoparticles by using the hyper-Rayleigh scattering technique

被引:108
作者
Ray, PC [1 ]
机构
[1] Jackson State Univ, Dept Chem, Jackson, MS 39217 USA
关键词
base pairs; DNA structures; hyper-Rayleigh scattering; nanostructures;
D O I
10.1002/anie.200503114
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
(Graph Presented) Highly sensitive: The hyper-Rayleigh Scattering (HRS) technique has been used to achieve the ultrasensitive detection of single base-pair mismatches in oligonucleotide strands without any modification of DNA. A very distinct HRS intensity change is observed after hybridization even at the concentration of 10-nanomolar probe single-stranded DNA. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码:1151 / 1154
页数:4
相关论文
共 40 条
[1]   The use of nanocrystals in biological detection [J].
Alivisatos, P .
NATURE BIOTECHNOLOGY, 2004, 22 (01) :47-52
[2]  
ANTIONE IR, 2004, J CHEM PHYS, V120, P10748
[3]   Three-dimensional nonlinear optical chromophores based on through-space delocalization [J].
Bartholomew, GP ;
Ledoux, I ;
Mukamel, S ;
Bazan, GC ;
Zyss, J .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (45) :13480-13485
[4]  
Bontidean I, 2001, ANGEW CHEM INT EDIT, V40, P2676, DOI 10.1002/1521-3773(20010716)40:14<2676::AID-ANIE2676>3.0.CO
[5]  
2-5
[6]  
BONTIDEAN I, 2001, ANGEW CHEM, V113, P2748
[7]   Nanoparticles with Raman spectroscopic fingerprints for DNA and RNA detection [J].
Cao, YWC ;
Jin, RC ;
Mirkin, CA .
SCIENCE, 2002, 297 (5586) :1536-1540
[8]   HYPER-RAYLEIGH SCATTERING IN SOLUTION [J].
CLAYS, K ;
PERSOONS, A .
PHYSICAL REVIEW LETTERS, 1991, 66 (23) :2980-2983
[9]   Syntheses and spectroscopic and quadratic nonlinear optical properties of extended dipolar complexes with ruthenium(II) ammine electron donor and N-methylpyridinium acceptor groups [J].
Coe, BJ ;
Jones, LA ;
Harris, JA ;
Brunschwig, BS ;
Asselberghs, I ;
Clays, K ;
Persoons, A ;
Garín, J ;
Orduna, J .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (12) :3880-3891
[10]   Highly unusual effects of π-conjugation extension on the molecular linear and quadratic nonlinear optical properties of ruthenium(II) ammine complexes [J].
Coe, BJ ;
Jones, LA ;
Harris, JA ;
Brunschwig, BS ;
Asselberghs, I ;
Clays, K ;
Persoons, A .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (04) :862-863