Diagnostics of single base-mismatch DNA hybridization on gold nanoparticles by using the hyper-Rayleigh scattering technique

被引:108
作者
Ray, PC [1 ]
机构
[1] Jackson State Univ, Dept Chem, Jackson, MS 39217 USA
关键词
base pairs; DNA structures; hyper-Rayleigh scattering; nanostructures;
D O I
10.1002/anie.200503114
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
(Graph Presented) Highly sensitive: The hyper-Rayleigh Scattering (HRS) technique has been used to achieve the ultrasensitive detection of single base-pair mismatches in oligonucleotide strands without any modification of DNA. A very distinct HRS intensity change is observed after hybridization even at the concentration of 10-nanomolar probe single-stranded DNA. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码:1151 / 1154
页数:4
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