Is plasmid-mediated quinolone resistance a clinically significant problem?

被引:74
作者
Poirel, L. [1 ]
Cattoir, V. [1 ,2 ]
Nordmann, P. [1 ]
机构
[1] Univ Paris 11, Hop Bicetre,Serv Bacteriol Virol Hygiene, INSERM,U914, Assistanc Publ Hop Paris,Fac Med Paris Sud, F-94275 Le Kremlin Bicetre, France
[2] Univ Paris 11, Serv Bacteriol Virol Hygiene, Hop Henri Mondor, Assistanc Publ Hop Paris,Fac Med Creteil, F-94275 Le Kremlin Bicetre, France
关键词
AAC(6')-Ib-cr; plasmid-mediated; QepA; QnrA; quinolones; resistance;
D O I
10.1111/j.1469-0691.2007.01930.x
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Although resistance to quinolones is commonly chromosomally-encoded in Enterobacteriaceae, the emergence of plasmid-mediated quinolone resistance (PMQR) has also been reported, with at least three known resistance mechanisms to date, i.e., Qnr, aminoglycoside acetyltransferase AAC(6')-Ib-cr and QepA. Qnr proteins protect target enzymes (DNA gyrase and type IV topoisomerase) from quinolone inhibition, the AAC(6')-Ib-cr enzyme acetylates norfloxacin and ciprofloxacin, and the QepA efflux pump extrudes hydrophilic fluoroquinolones. Although these PMQR determinants confer only low-level resistance to quinolones and/or fluoroquinolones, they may provide a favourable background in which the selection of additional chromosomally-encoded quinolone resistance mechanisms can occur.
引用
收藏
页码:295 / 297
页数:3
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