Phenylpiperazine derivatives with strong affinity for 5HT1A, D2A and D3 receptors

被引:30
作者
Terán, C
Santana, L [1 ]
Uriarte, E
Fall, Y
Unelius, L
Tolf, BR
机构
[1] Univ Santiago, Fac Pharm, Dept Organ Chem, E-15706 Santiago, Spain
[2] Univ Vigo, Dept Phys Chem & Organ Chem, Vigo 36200, Spain
[3] Astra Arcus AB, Preclin Res & Dev, S-15185 Sodertalje, Sweden
关键词
D O I
10.1016/S0960-894X(98)00646-5
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Four 7-[3-(4-phenyl-1-piperazinyl)propoxy]coumarins were synthesized. The affinities of these compounds for DA (D-2A, D-3) and 5HT(1A) receptors were evaluated for their ability to displace [H-3]-raclopride and [H-3]-8-OH-DPAT respectively from their specific binding sites. The affinities of the target compounds were all in the nanomolar range and followed the order 5-HT1A > D-2 > D-3 (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:3567 / 3570
页数:4
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