Total syntheses of justicidin B and retrojusticidin B using a tandem Horner-Emmons-Claisen condensation sequence

被引：25

作者：

Harrowven, DC ^{[1
]}

Bradley, M

Castro, JL

Flanagan, SR

机构：

[1] Univ Southampton, Dept Chem, Southampton SO17 1BJ, Hants, England

[2] Merck Sharp & Dohme Ltd, Neurosci Res Ctr, Harlow CM20 2QR, Essex, England

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 39期

关键词：

natural products; annulation; lignans; Horner-Emmons; Claisen condensation;

D O I：

10.1016/S0040-4039(01)01436-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Short syntheses of justicidin B 1 and retrojusticidin B 4 are reported. The key feature is a new annulation reaction, involving a base induced union of ketoaldehyde 2 and phosphonate 3. that is used to construct the highly substituted naphthalene core. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：6973 / 6975

页数：3

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