The synthesis of indolo- and pyrrolo[2,1-a]isoquinolines

被引：27

作者：

de Koning, CB ^{[1
]}

Michael, JP ^{[1
]}

Pathak, R ^{[1
]}

van Otterlo, WAL ^{[1
]}

机构：

[1] Univ Witwatersrand, Inst Mol Sci, Sch Chem, ZA-2050 Johannesburg, South Africa

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

isoquinolines; potassium t-butoxide;

D O I：

10.1016/j.tetlet.2003.12.020

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of fused isoquinolines from N-benzyl protected indoles and pyrroles is described. For example, treatment of t-butyl-2-(2-formyl-3,4-dihydro-1-naphthalenyl)-3-methyl-1H-indole-l-carboxylate with KOBu' in DMF provided 14-methyl-8-phenylbenzo[h]indolo[2,1-a]isoquinoline in good yield. Analogous N-benzylpyrrole precursors could similarly be cyclized to give pyrrolo[2,1-a]isoquinolines. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：1117 / 1119

页数：3

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