Novel concepts in directed biaryl synthesis.: Part 107.: Synthesis of enantiopure axially chiral C3-symmetric tripodal ligands and their application as catalysts in the asymmetric addition of dialkylzinc to aldehydes

被引：45

作者：

Bringmann, G ^{[1
]}

Pfeifer, RM ^{[1
]}

Rummey, C ^{[1
]}

Hartner, K ^{[1
]}

Breuning, M ^{[1
]}

机构：

[1] Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 18期

关键词：

ENANTIOSELECTIVE ADDITION; NATURAL-PRODUCTS; AROMATIC-ALDEHYDES; CARBONYL-COMPOUNDS; LACTONE CONCEPT; REAGENTS; DIETHYLZINC; RECOGNITION; DERIVATIVES; COMPLEXES;

D O I：

10.1021/jo034697t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The enantioselective synthesis of a novel-type C-3-symmetric tripodal ligand that is composed of a central mesitylene-derived core and three functionalized, axially chiral biaryl subunits is described. The triol (M,M,M)-3 is a suitable catalyst for the enantioselective addition of dialkylzinc to various aromatic aldehydes with asymmetric inductions of up to 98% ee.

引用

页码：6859 / 6863

页数：5

共 35 条

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