Facultative heterochromatin: Is there a distinctive molecular signature?

被引：358

作者：

Trojer, Patrick ^{[1
]}

Reinberg, Danny ^{[1
]}

机构：

[1] NYU, Dept Biochem, Howard Hughes Med Inst, New York, NY 10016 USA

来源：

MOLECULAR CELL | 2007年 / 28卷 / 01期

关键词：

D O I：

10.1016/j.molcel.2007.09.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Latin word "facultas" literally means "opportunity." Facultative heterochromatin (MC) then designates genomic regions in the nucleus of a eukaryotic cell that have the opportunity to adopt open or compact conformations within temporal and spatial contexts. This review focuses on the molecular and functional aspects of fHC that distinguish it from constitutive heterochromatin (cHC) and euchromatin (EC) and discusses various concepts regarding the regulation of fHC structure. We begin by revisiting the historical developments that gave rise to our current appreciation of MC.

引用

页码：1 / 13

页数：13

共 120 条

[21] Histone macroH2A1 is concentrated in the inactive X chromosome of female mammals [J].

Costanzi, C ;

Pehrson, JR .

NATURE, 1998, 393 (6685) :599-601

[22] Heterochromatin-many flavours, common themes [J].

Craig, JM .

BIOESSAYS, 2005, 27 (01) :17-28

[23] Linking the Rb and polycomb pathways [J].

Dahiya, A ;

Wong, S ;

Gonzalo, S ;

Gavin, M ;

Dean, DC .

MOLECULAR CELL, 2001, 8 (03) :557-568

[24] Solvent mediated interactions in the structure of the nucleosome core particle at 1.9 Å resolution [J].

Davey, CA ;

Sargent, DF ;

Luger, K ;

Maeder, AW ;

Richmond, TJ .

JOURNAL OF MOLECULAR BIOLOGY, 2002, 319 (05) :1097-1113

[25] Differential histone modifications mark mouse imprinting control regions during spermatogenesis [J].

Delaval, Katia ;

Govin, Jerome ;

Cerqueira, Frederique ;

Rousseaux, Sophie ;

Khochbin, Saadi ;

Feil, Robert .

EMBO JOURNAL, 2007, 26 (03) :720-729

[26] The E2F transcriptional network: old acquaintances with new faces [J].

Dimova, DK ;

Dyson, NJ .

ONCOGENE, 2005, 24 (17) :2810-2826

[27] Chromatin fiber folding: Requirement for the histone H4N-terminal tail [J].

Dorigo, B ;

Schalch, T ;

Bystricky, K ;

Richmond, TJ .

JOURNAL OF MOLECULAR BIOLOGY, 2003, 327 (01) :85-96

[28] Mechanism of polymerase II transcription repression by the histone variant macroH2A [J].

Doyen, CM ;

An, WJ ;

Angelov, D ;

Bondarenko, V ;

Mietton, F ;

Studitsky, VM ;

Hamiche, A ;

Roeder, RG ;

Bouvet, P ;

Dimitrov, S .

MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (03) :1156-1164

[29] Three-dimensional reconstruction of painted human interphase chromosomes: Active and inactive X chromosome territories have similar volumes but differ in shape and surface structure [J].

Eils, R ;

Dietzel, S ;

Bertin, E ;

Schrock, E ;

Speicher, MR ;

Ried, T ;

RobertNicoud, M ;

Cremer, C ;

Cremer, T .

JOURNAL OF CELL BIOLOGY, 1996, 135 (06) :1427-1440

[30] Histone H1 depletion in mammals alters global chromatin structure but causes specific changes in gene regulation [J].

Fan, YH ;

Nikitina, T ;

Zhao, J ;

Fleury, TJ ;

Bhattacharyya, R ;

Bouhassira, EE ;

Stein, A ;

Woodcock, CL ;

Skoultchi, AI .

CELL, 2005, 123 (07) :1199-1212

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