Facultative heterochromatin: Is there a distinctive molecular signature?

被引：358

作者：

Trojer, Patrick ^{[1
]}

Reinberg, Danny ^{[1
]}

机构：

[1] NYU, Dept Biochem, Howard Hughes Med Inst, New York, NY 10016 USA

来源：

MOLECULAR CELL | 2007年 / 28卷 / 01期

关键词：

D O I：

10.1016/j.molcel.2007.09.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Latin word "facultas" literally means "opportunity." Facultative heterochromatin (MC) then designates genomic regions in the nucleus of a eukaryotic cell that have the opportunity to adopt open or compact conformations within temporal and spatial contexts. This review focuses on the molecular and functional aspects of fHC that distinguish it from constitutive heterochromatin (cHC) and euchromatin (EC) and discusses various concepts regarding the regulation of fHC structure. We begin by revisiting the historical developments that gave rise to our current appreciation of MC.

引用

页码：1 / 13

页数：13

共 120 条

[91] Polycomb group and trithorax group proteins in Arabidopsis [J].

Pien, Stephane ;

Grossniklaus, Ueli .

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 2007, 1769 (5-6) :375-382

[92] Polycombing the genome: PcG, trxG, and chromatin silencing [J].

Pirrotta, V .

CELL, 1998, 93 (03) :333-336

[93] On the use of the word 'epigenetic' [J].

Ptashne, Mark .

CURRENT BIOLOGY, 2007, 17 (07) :R233-R236

[94] Polycomb/Trithorax response elements and epigenetic memory of cell identity [J].

Ringrose, Leonie ;

Paro, Renato .

DEVELOPMENT, 2007, 134 (02) :223-232

[95] Functional demarcation of active and silent chromatin domains in human HOX loci by Noncoding RNAs [J].

Rinn, John L. ;

Kertesz, Michael ;

Wang, Jordon K. ;

Squazzo, Sharon L. ;

Xu, Xiao ;

Brugmann, Samantha A. ;

Goodnough, L. Henry ;

Helms, Jill A. ;

Farnham, Peggy J. ;

Segal, Eran ;

Chang, Howard Y. .

CELL, 2007, 129 (07) :1311-1323

[96] Overlapping roles of the methylated DNA-binding protein MBD1 and polycomb group proteins in transcriptional repression of HOXA genes and heterochromatin foci formation [J].

Sakamoto, Yasuo ;

Watanabe, Sugiko ;

Ichimura, Takaya ;

Kawasuji, Michio ;

Koseki, Haruhiko ;

Baba, Hideo ;

Nakao, Mitsuyoshi .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (22) :16391-16400

[97] Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer [J].

Schlesinger, Yeshayahu ;

Straussman, Ravid ;

Keshet, Ilana ;

Farkash, Shlomit ;

Hecht, Merav ;

Zimmerman, Joseph ;

Eden, Eran ;

Yakhini, Zohar ;

Ben-Shushan, Etti ;

Reubinoff, Benjamin E. ;

Bergman, Yehudit ;

Simon, Itamar ;

Cedar, Howard .

NATURE GENETICS, 2007, 39 (02) :232-236

[98] Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing [J].

Schoeftner, Stefan ;

Sengupta, Aditya K. ;

Kubicek, Stefan ;

Mechtler, Karl ;

Spahn, Laura ;

Koseki, Haruhiko ;

Jenuwein, Thomas ;

Wutz, Anton .

EMBO JOURNAL, 2006, 25 (13) :3110-3122

[99] Genome regulation by polycomb and trithorax proteins [J].

Schuettengruber, Bernd ;

Chourrout, Daniel ;

Vervoort, Michel ;

Leblanc, Benjamin ;

Cavalli, Giacomo .

CELL, 2007, 128 (04) :735-745

[100] Polycomb silencing mechanisms and the management of genomic programmes [J].

Schwartz, Yuri B. ;

Pirrotta, Vincenzo .

NATURE REVIEWS GENETICS, 2007, 8 (01) :9-22

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