Domino palladium(II)-mediated rearrangement-oxidative cyclization of β-aminocyclopropanols

被引：24

作者：

Cicchi, S

Revuelta, J

Zanobini, A

Betti, M

Brandi, A

机构：

[1] Univ Florence, Dipartimento Chim Organ Ugo Schiff, I-50019 Sesto Fiorentino, FI, Italy

[2] CNR, ICCOM, I-50019 Sesto Fiorentino, FI, Italy

来源：

SYNLETT | 2003年 / 15期

关键词：

domino reactions; palladium; Wacker reactions; heterocycles; catalysis;

D O I：

10.1055/s-2003-42122

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

beta-Aminocyclopropanols were transformed, in a domino process catalyzed by Pd(II) salts, into the corresponding 2,3-dihydro-1H-pyridin-4-ones. Conversely the use of a Pd(0) derivative, Pd(dba)(2), afforded the corresponding tetrahydropyrid-4-ones. The saturated derivatives were also obtained, in better yields, using Pd(II) and Cu(OAc)(2) as stoichiometric oxidant.

引用

收藏

页码：2305 / 2308

页数：4

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