Harnessing the potential of induced pluripotent stem cells for regenerative medicine

被引：364

作者：

Wu, Sean M. ^{[1
,2
]}

Hothedlinger, Konrad ^{[2
,3
,4
,5
]}

机构：

[1] Massachusetts Gen Hosp, Cardiovasc Res Ctr, Div Cardiol, Boston, MA 02114 USA

[2] Harvard Stem Cell Inst, Cambridge, MA 02138 USA

[3] Massachusetts Gen Hosp, Ctr Regenerat Med, Boston, MA 02114 USA

[4] Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA

[5] Harvard Univ, Dept Stem Cell & Regenerat Biol, Howard Hughes Med Inst, Cambridge, MA 02138 USA

来源：

NATURE CELL BIOLOGY | 2011年 / 13卷 / 05期

关键词：

FUNCTIONAL CARDIOMYOCYTES; MYOCARDIAL-INFARCTION; EFFICIENT GENERATION; DIRECT CONVERSION; HUMAN FIBROBLASTS; SMALL MOLECULES; MOTOR-NEURONS; SOMATIC-CELLS; COPY NUMBER; IPS CELLS;

D O I：

10.1038/ncb0511-497

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The discovery of methods to convert somatic cells into induced pluripotent stem cells (iPSCs) through expression of a small combination of transcription factors has raised the possibility of producing custom-tailored cells for the study and treatment of numerous diseases. Indeed, iPSCs have already been derived from patients suffering from a large variety of disorders. Here we review recent progress that has been made in establishing iPSC-based disease models, discuss associated technical and biological challenges, and highlight possible solutions to overcome these barriers. We believe that a better understanding of the molecular basis of pluripotency, cellular reprogramming and lineage-specific differentiation of iPSCs is necessary for progress in regenerative medicine.

引用

页码：497 / 505

页数：9

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