Transcriptional control of human p53-regulated genes

被引：1530

作者：

Riley, Todd ^{[1
,2
]}

Sontag, Eduardo ^{[2
,3
]}

Chen, Patricia ^{[1
]}

Levine, Arnold ^{[1
,4
]}

机构：

[1] Inst Adv Study, Princeton, NJ 08540 USA

[2] Rutgers State Univ, BioMaPS Inst Quantitat Biol, Piscataway, NJ USA

[3] Rutgers State Univ, Dept Math, Piscataway, NJ USA

[4] Canc Inst New Jersey, New Brunswick, NJ USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2008年 / 9卷 / 05期

基金：

英国科研创新办公室;

关键词：

D O I：

10.1038/nrm2395

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The p53 protein regulates the transcription of many different genes in response to a wide variety of stress signals. Following DNA damage, p53 regulates key processes, including DNA repair, cell-cycle arrest, senescence and apoptosis, in order to suppress cancer. This Analysis article provides an overview of the current knowledge of p53-regulated genes in these pathways and others, and the mechanisms of their regulation. In addition, we present the most comprehensive list so far of human p53-regulated genes and their experimentally validated, functional binding sites that confer p53 regulation.

引用

页码：402 / 412

页数：11

共 103 条

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