Optical coherence Doppler tomography quantifies laser speckle contrast imaging for blood flow imaging in the rat cerebral cortex

被引：19

作者：

Luo, Zhongchi ^{[1
,3
]}

Wang, Zhenguo ^{[1
]}

Yuan, Zhijia ^{[1
]}

Dua, Congwu ^{[2
,3
]}

Pan, Yingtian ^{[1
]}

机构：

[1] SUNY Stony Brook, Dept Biomed Engn, Stony Brook, NY 11794 USA

[2] SUNY Stony Brook, Dept Anesthesiol, Stony Brook, NY 11794 USA

[3] Brookhaven Natl Lab, Dept Med, Upton, NY 11973 USA

来源：

OPTICS LETTERS | 2008年 / 33卷 / 10期

关键词：

D O I：

10.1364/OL.33.001156

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

A dual-imaging modality is demonstrated for high-resolution quantitative imaging of local cerebral blood flow in the rat cortex by combining simultaneous spectral-domain Doppler optical coherence tomography (SDOCT) and full-field laser speckle contrast imaging (LSCI). Preliminary studies in tissue flow phantom and cocaine-induced cerebral blood flow changes indicated that by correlating coregistered cortical arterial blood flow, the relative measurement of flow changes by LSCI could be accurately calibrated by the absolute flow imaging provided by SDOCT (least square fit, r(2) approximate to 0.96). Quantitative LSCI of cerebral blood flow is crucial to the quantitative analyses of the spatiotemporal hemodynamics of functional brain activations and thus improved understanding of neural process. (C) 2008 Optical Society of America.

引用

页码：1156 / 1158

页数：3

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