Diffusion MRI of complex neural architecture

被引:546
作者
Tuch, DS
Reese, TG
Wiegell, MR
Wedeen, VJ
机构
[1] Massachusetts Gen Hosp, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
[2] Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1016/S0896-6273(03)00758-X
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
While functional brain imaging methods can locate the cortical regions subserving particular cognitive functions, the connectivity between the functional areas of the human brain remains poorly understood. Recently, investigators have proposed a method to image neural connectivity noninvasively using a magnetic resonance imaging method called diffusion tensor imaging (DTI). DTI measures the molecular diffusion of water along neural pathways. Accurate reconstruction of neural connectivity patterns from DTI has been hindered, however, by the inability of DTI to resolve more than a single axon direction within each imaging voxel. Here, we present a novel magnetic resonance imaging technique that can resolve multiple axon directions within a single voxel. The technique, called q-ball imaging, can resolve intravoxel white matter fiber crossing as well as white matter insertions into cortex. The ability of q-ball imaging to resolve complex intravoxel fiber architecture eliminates a key obstacle to mapping neural connectivity in the human brain noninvasively.
引用
收藏
页码:885 / 895
页数:11
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