Stereocontrolled synthesis of 20,21-dihydro N-methylwelwitindolinone B isothiocyanate

被引：26

作者：

Bhat, Vikram ^{[1
]}

Rawal, Viresh H. ^{[1
]}

机构：

[1] Univ Chicago, Dept Chem, Chicago, IL 60637 USA

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 34期

关键词：

WELWITINDOLINONE; CONSTRUCTION; EFFICIENT; ALCOHOLS; WELWISTATIN; FISCHERINDOLES; CHLORINATION; OXIDATION;

D O I：

10.1039/c1cc13498a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Described is a concise synthesis of the 20,21-dihydro analog of N-methylwelwitindolinone B isothiocyanate, wherein a cationic homoallyl to cyclopropylmethyl rearrangement is circumvented by hydrogenation of the offending double bond.

引用

页码：9705 / 9707

页数：3

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