Effect of adrenomedullin administration on acetic acid-induced colitis in rats

被引：38

作者：

Ashizuka, S ^{[1
]}

Ishikawa, N ^{[1
]}

Kato, J ^{[1
]}

Yamaga, J ^{[1
]}

Inatsu, H ^{[1
]}

Eto, T ^{[1
]}

Kitamura, K ^{[1
]}

机构：

[1] Miyazaki Univ, Miyazaki Med Coll, Dept Internal Med 1, Miyazaki 8891692, Japan

来源：

PEPTIDES | 2005年 / 26卷 / 12期

关键词：

acetic acid; adrenomedullin; colitis; inflammatory bowel disease; T helper 2 cells;

D O I：

10.1016/j.peptides.2005.05.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Adrenomedullin (AM) administered intracolonically ameliorated the severity of acetic acid-induced colonic ulceration in rats. Ulcers were induced by subserosal injection of acetic acid into the colon. AM-treated group was administered 0.25-1.0 mu g of AM in 0.5 ml of saline intracolonically once a day; the control group received only saline. AM administration dose-dependently and significantly reduced the size of the ulcerative lesions, the associated edema, and the infiltration of the affected area by inflammatory cells. AM also reduced tissue levels of interleukin-6, but not interferon-gamma. AM reduces the severity of acetic acid-induced colitis in rats, probably by inhibiting the production and/or release of Th-2 cell-derived factors such as interleukin-6. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：2610 / 2615

页数：6

共 35 条

[1] Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation:: Evidence in Crohn disease and experimental colitis in vivo
Atreya, R
Mudter, J
Finotto, S
Müllberg, J
Jostock, T
Wirtz, S
Schütz, M
Bartsch, B
Holtmann, M
Becker, C
Strand, D
Czaja, J
Schlaak, JF
Lehr, HA
Autschbach, F
Schürmann, G
Nishimoto, N
Yoshizaki, K
Ito, H
Kishimoto, T
Galle, PR
Rose-John, S
Neurath, MF
[J]. NATURE MEDICINE, 2000, 6 (05) : 583 - 588
[2] Gastroprotective effect of adrenomedullin administered subcutaneously in the rat
Clementi, G
Caruso, A
Cutuli, VMC
Mangano, NG
Salomone, S
Lempereur, L
Prato, A
Matera, M
Amico-Roxas, M
[J]. PEPTIDES, 2002, 23 (06) : 1149 - 1153
[3] Specific targeting of IL-6 signalling pathway: a new way to treat IBD?
Desreumaux, P
[J]. GUT, 2000, 47 (04) : 465 - 466
[4] Kinetics of cytokine expression during healing of acute colitis in mice
Dieleman, LA
Elson, CO
Tennyson, GS
Beagley, KW
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 1996, 271 (01): : G130 - G136
[5] DINARELLO CA, 1993, NEW ENGL J MED, V328, P106
[6] Hapten-induced colitis is associated with colonic patch hypertrophy and T helper cell 2-type responses
Dohi, T
Fujihashi, K
Rennert, PD
Iwatani, K
Kiyono, H
McGhee, JR
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (08) : 1169 - 1179
[7] ACETIC ACID-INDUCED COLITIS IN THE RAT - A REPRODUCIBLE EXPERIMENTAL-MODEL FOR ACUTE ULCERATIVE-COLITIS
FABIA, R
WILLEN, R
ARRAJAB, A
ANDERSSON, R
AHREN, B
BENGMARK, S
[J]. EUROPEAN SURGICAL RESEARCH, 1992, 24 (04) : 211 - 225
[8] Giacomelli R, 1998, CLIN EXP IMMUNOL, V111, P532
[9] Adrenomedullin stimulates somatostatin and thus inhibits histamine and acid secretion in the fundus of the stomach
Hirsch, AB
McCuen, RW
Arimura, A
Schubert, ML
[J]. REGULATORY PEPTIDES, 2003, 110 (03) : 189 - 195
[10] Interleukin-6 and soluble interleukin-6 receptor in the colonic mucosa of inflammatory bowel disease
Hosokawa, T
Kusugami, K
Ina, K
Ando, T
Shinoda, M
Imada, A
Ohsuga, M
Sakai, T
Matsuura, T
Ito, K
Kaneshiro, K
[J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 1999, 14 (10) : 987 - 996

← 1 2 3 4 →