A New and Practical Grignard-Coupling-Fluorination Sequence: Synthesis of 2-Aryl Fluoroarenes

被引：17

作者：

Anbarasan, Pazhamalai ^{[1
]}

Neumann, Helfried ^{[1
]}

Beller, Matthias ^{[1
]}

机构：

[1] Univ Rostock, Katalyse eV, Leibniz Inst, D-18059 Rostock, Germany

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2010年 / 5卷 / 08期

关键词：

arylfluorides; arynes; domino reactions; fluorination; Grignard reaction; ELECTROPHILIC FLUORINATION; FUNCTIONALIZED ARYL; EFFICIENT SYNTHESIS; HIGHLY EFFICIENT; REAGENTS; MAGNESIUM; SALTS; ARYLMAGNESIUM; SELECTFLUOR; ELIMINATION;

D O I：

10.1002/asia.201000288

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new strategy for the synthesis of 2-aryl-and 2-heteroaryl fluoroarenes has been developed. An intermolecular domino Grignard-coupling-fluorination sequence affords a range of 2-fluorobiaryls from aryl bromides under mild conditions. This methodology can be further extended to the synthesis of 2′-aryl-2-fluorobiphenyls. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1775 / 1778

页数：4

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